2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester

Base Information

• Chemical Name: 2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester
• CAS No.: 197979-53-6
• Molecular Formula: C₂₂H₂₂O₆
• Molecular Weight: 382.413

Synonyms:2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester

Chemical Property of 2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester

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Technology Process of 2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester

There total 2 articles about 2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C24H26O7 (1094172-77-6) → 2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester (197979-53-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2008.10.067

Reference yield:

1-(3,5-dimethoxyphenyl)ethan-1-one (39151-19-4) + dimethyl (E)-benzylidenesuccinate (65859-90-7) → 2-[1-(3',5'-dimethoxyphenyl)-(E)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester (197979-65-0) + 2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester (197979-53-6)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 20 ℃; for 5h; optical yield given as %de;

DOI:10.1021/op9000719

Reference yield: 81.0%

N-amino-N'-methylpiperazine (6928-85-4) + 2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester (197979-53-6) + oxazolyl chloride (95458-77-8) → methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate (197979-66-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

C₂₄H₂₆O₇

1-(3,5-dimethoxyphenyl)ethan-1-one

dimethyl (E)-benzylidenesuccinate

Downstream raw materials:

methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

C₂₇H₃₂N₂O₅

methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(1-methylpiperizin-4-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyridin-3-ylcarbamoyl)vinyl]-2-butenoate

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