methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

Base Information

Chemical Name:methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate
CAS No.:197979-66-1
Molecular Formula:C₂₇H₃₃N₃O₅
Molecular Weight:479.576
Hs Code.:

Synonyms:methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

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Chemical Property of methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

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Technology Process of methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

There total 3 articles about methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 6928-85-4
N-amino-N'-methylpiperazine

: 197979-53-6
2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester

: 95458-77-8
oxazolyl chloride

: 197979-66-1
methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6928-85-4
N-amino-N'-methylpiperazine

: C₂₂H₂₁ClO₅

: 197979-66-1
methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2008.10.067

Reference yield:

: 6928-85-4
N-amino-N'-methylpiperazine

: 197979-53-6
2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester

: 197979-66-1
methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

Guidance literature:: 2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃;

N-amino-N'-methylpiperazine; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate;
DOI:10.1016/j.bmc.2010.01.032