4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide

Base Information

Chemical Name:4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide
CAS No.:855231-08-2
Molecular Formula:C₂₇H₂₃FN₂O₂
Molecular Weight:426.49
Hs Code.:

Synonyms:4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide

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Chemical Property of 4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide

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Technology Process of 4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide

There total 6 articles about 4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 855231-06-0
4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid

: 62-53-3
aniline

: 855231-08-2
4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide

Guidance literature:: 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

aniline; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With hydrogenchloride; sodium hydrogencarbonate; more than 3 stages;

Reference yield:

: 1027039-32-2
C₂₁H₁₇ClFNO₂

: 62-53-3
aniline

: 855231-08-2
4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 25 ℃; for 12h;
DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

: 855231-02-6
4-(4-fluoro-phenyl)-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester

: 855231-08-2
4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 4 steps

1: POCl₃ / 1,2-dichloro-ethane / 3 h / 80 °C

2: 100 percent / NaOH / methanol / 2 h / 60 °C

3: SOCl₂ / 80 °C

4: Et₃N / tetrahydrofuran / 12 h / 25 °C

With sodium hydroxide; thionyl chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; 1: Vilsmeir-Haack reaction;
DOI:10.1016/j.bmcl.2007.05.096