5-[2-[2-(3-bromo-2-hydroxypropoxy)-4-dibutylaminophenyl]vinyl]thiophene-2-carboaldehyde

Base Information

Chemical Name:5-[2-[2-(3-bromo-2-hydroxypropoxy)-4-dibutylaminophenyl]vinyl]thiophene-2-carboaldehyde
CAS No.:1267604-34-1
Molecular Formula:C₂₄H₃₂BrNO₃S
Molecular Weight:494.493
Hs Code.:

Synonyms:5-[2-[2-(3-bromo-2-hydroxypropoxy)-4-dibutylaminophenyl]vinyl]thiophene-2-carboaldehyde

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Chemical Property of 5-[2-[2-(3-bromo-2-hydroxypropoxy)-4-dibutylaminophenyl]vinyl]thiophene-2-carboaldehyde

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Technology Process of 5-[2-[2-(3-bromo-2-hydroxypropoxy)-4-dibutylaminophenyl]vinyl]thiophene-2-carboaldehyde

There total 6 articles about 5-[2-[2-(3-bromo-2-hydroxypropoxy)-4-dibutylaminophenyl]vinyl]thiophene-2-carboaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256155-38-0
5-[2-(4-dibutylamino-2-hydroxyphenyl)vinyl]thiophene-2-carboaldehyde

: 3132-64-7,82584-73-4
1,2-Epoxy-3-bromopropane

: 1267604-34-1
5-[2-[2-(3-bromo-2-hydroxypropoxy)-4-dibutylaminophenyl]vinyl]thiophene-2-carboaldehyde

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 4h;

Reference yield:

: N,N-dibutyl-4-amino-2-hydroxy-benzaldehyde

: 1267604-34-1
5-[2-[2-(3-bromo-2-hydroxypropoxy)-4-dibutylaminophenyl]vinyl]thiophene-2-carboaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 3.5 h / 20 °C

2.1: phenyllithium / dibutyl ether; tetrahydrofuran / 3 h / Cooling with ice; Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -73 - -70 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 20 °C

5.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / 1-methyl-pyrrolidin-2-one / 4 h / 60 °C

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; potassium carbonate; phenyllithium; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dibutyl ether; N,N-dimethyl-formamide;

Reference yield:

: 1256155-29-9
4-dibutylamino-2-(tert-butyldiphenylsiloxy)benzaldehyde

: 1267604-34-1
5-[2-[2-(3-bromo-2-hydroxypropoxy)-4-dibutylaminophenyl]vinyl]thiophene-2-carboaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: phenyllithium / dibutyl ether; tetrahydrofuran / 3 h / Cooling with ice; Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -73 - -70 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 20 °C

4.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / 1-methyl-pyrrolidin-2-one / 4 h / 60 °C

With n-butyllithium; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; potassium carbonate; phenyllithium; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dibutyl ether;