1-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}piperidin-4-ol

Base Information

Chemical Name:1-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}piperidin-4-ol
CAS No.:1382993-42-1
Molecular Formula:C₂₀H₂₅ClN₆O₂
Molecular Weight:416.911
Hs Code.:

Synonyms:1-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}piperidin-4-ol

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Chemical Property of 1-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}piperidin-4-ol

Chemical Property:

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Technology Process of 1-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}piperidin-4-ol

There total 5 articles about 1-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382995-38-1
1-[3-(1-aminoethyl)-5-chloro-2-methoxy-6-methylphenyl]piperidin-4-ol

: 767-69-1
6-bromopurine

: 1382993-42-1
1-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}piperidin-4-ol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 90 ℃; Inert atmosphere;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1382993-42-1
1-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}piperidin-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1: N-iodo-succinimide / acetic acid / 18 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: potassium phosphate; ethylene glycol / copper(l) iodide / isopropyl alcohol / 80 °C

4: methanol; ammonium acetate; sodium cyanoborohydride / acetonitrile / 65 °C / Sealed tube

5: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 90 °C / Inert atmosphere

With methanol; potassium phosphate; N-iodo-succinimide; ammonium acetate; sodium cyanoborohydride; potassium carbonate; ethylene glycol; N-ethyl-N,N-diisopropylamine; copper(l) iodide; In acetic acid; isopropyl alcohol; acetone; acetonitrile;

Reference yield:

: 292144-86-6
1-(5-chloro-2-hydroxy-3-iodo-4-methylphenyl)ethan-1-one

: 1382993-42-1
1-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}piperidin-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / Reflux

2: potassium phosphate; ethylene glycol / copper(l) iodide / isopropyl alcohol / 80 °C

3: methanol; ammonium acetate; sodium cyanoborohydride / acetonitrile / 65 °C / Sealed tube

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 90 °C / Inert atmosphere

With methanol; potassium phosphate; ammonium acetate; sodium cyanoborohydride; potassium carbonate; ethylene glycol; N-ethyl-N,N-diisopropylamine; copper(l) iodide; In isopropyl alcohol; acetone; acetonitrile;