Technology Process of (2S,3R)-2-[2-(benzyloxy)ethyl]-3-(chloromethyl)oxirane
There total 5 articles about (2S,3R)-2-[2-(benzyloxy)ethyl]-3-(chloromethyl)oxirane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrachloromethane; sodium hydrogencarbonate; triphenylphosphine;
for 4h;
Heating;
DOI:10.1016/j.tetasy.2006.11.045
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: magnesium; ethyl bromide / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux
3.1: L-(+)-diisopropyl tartrate; titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; toluene / 12 h / -25 °C / Inert atmosphere; Molecular sieve
4.1: triphenylphosphine; sodium hydrogencarbonate; tetrachloromethane / 6 h / Inert atmosphere; Reflux
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; tetrachloromethane; lithium aluminium tetrahydride; ethyl bromide; L-(+)-diisopropyl tartrate; sodium hydrogencarbonate; magnesium; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; toluene;
3.1: |Sharpless Asymmetric Epoxidation / 4.1: |Sharpless Asymmetric Epoxidation;
DOI:10.3998/ark.5550190.p008.453
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux
2: L-(+)-diisopropyl tartrate; titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; toluene / 12 h / -25 °C / Inert atmosphere; Molecular sieve
3: triphenylphosphine; sodium hydrogencarbonate; tetrachloromethane / 6 h / Inert atmosphere; Reflux
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; tetrachloromethane; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; sodium hydrogencarbonate; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; toluene;
2: |Sharpless Asymmetric Epoxidation / 3: |Sharpless Asymmetric Epoxidation;
DOI:10.3998/ark.5550190.p008.453
