22273-77-4

Basic information

• Product Name: Benzene, [(3-butynyloxy)methyl]-
• Synonyms: benzyl 3-butenyl ether;benzyl but-3-yn-1-yl ether
• CAS NO: 22273-77-4
• Molecular Formula: C11H12O
• Molecular Weight: 288.195
• Mol File: 22273-77-4.mol
• Article Data: 54

Chemical Properties

• CAS DataBase Reference: Benzene, [(3-butynyloxy)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(3-butynyloxy)methyl]-(22273-77-4)
• EPA Substance Registry System: Benzene, [(3-butynyloxy)methyl]-(22273-77-4)

Safety Data

• Hazardous Substances Data: 22273-77-4(Hazardous Substances Data)

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 106-96-7 propargyl bromide 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 70388-33-9 4-benzyloxybut-1-ene 
• 75927-49-0 pinacol vinylboronate 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 927-74-2 3-Butyn-1-ol 

Downstream Products

• 135679-73-1 (5-Benzyloxy-pent-2-ynyl)-methyl-(2,4,6-trimethoxy-benzyl)-amine 
• 181211-29-0 1-benzyloxy-(7R)-7-(methoxymethoxy)-3-tridecyne 
• 372074-88-9 (+/-)(SR)-1,7-(dibenzyloxy)hept-4-yn-2-ol 
• 128217-54-9 5-benzyloxy-2-(E)-pentenocarboxylic acid 

Relevant articles and documents

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Trans-AT polyketide synthases (PKSs) are a family of biosynthetically versatile modular type I PKSs that generate bioactive polyketides of impressive structural diversity. In this study, we detected, in the genome of several bacteria a cryptic, architectu

Electron donor-acceptor (EDA)-complex enabled SF5Cl addition on alkenes and alkynes

A new method for the addition of SF5Cl on unsaturated compounds was developed, based on the use of an electron donor-acceptor (EDA)-complex and visible light irradiation. The reaction does not require the presence of oxygen to proceed, compared

Ring-closing metathesis approaches towards the total synthesis of rhizoxins

Efforts are described towards the total synthesis of the bacterial macrolide rhizoxin F, which is a potent tubulin assembly and cancer cell growth inhibitor. A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by ring-closing olefin metathesis (RCM) between C(9) and C(10), either directly or by using relay substrates, but in no case was ringclosure achieved. Macrocycle formation was possible by ring-closing alkyne metathesis (RCAM) at the C(9)/C(10) site. The requisite diyne was obtained from advanced intermediates that had been prepared as part of the synthesis of the RCM substrates. While the direct conversion of the triple bond formed in the ring-closing step into the C(9)-C(10) E double bond of the rhizoxin macrocycle proved to be elusive, the corresponding Z isomer was accessible with high selectivity by reductive decomplexation of the biscobalt hexacarbonyl complex of the triple bond with ethylpiperidinium hypophosphite. Radical-induced double bond isomerization, full elaboration of the C(15) side chain, and directed epoxidation of the C(11)-C(12) double bond completed the total synthesis of rhizoxin F.