(S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide

Base Information

Chemical Name:(S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide
CAS No.:465520-11-0
Molecular Formula:C₂₂H₂₅FN₄O₃
Molecular Weight:412.464
Hs Code.:

Synonyms:(S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide

Suppliers and Price of (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide

Chemical Property:

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Technology Process of (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide

There total 14 articles about (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.42%

: (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]amine hydrochloride

: 108-24-7
acetic anhydride

: 465520-11-0
(S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

Reference yield:

: 108-24-7
acetic anhydride

: 735276-50-3
(S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]amine

: 465520-11-0
(S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: at 40 ℃; for 2h;
DOI:10.1016/S0960-894X(02)00043-4

Reference yield:

: 465520-07-4
(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol

: 465520-11-0
(S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: TEA / CH₂Cl₂ / 0 °C

2: NaN₃ / dimethylformamide / 80 °C

3: H₂ / Pd/C / ethanol; ethyl acetate

4: TEA / CH₂Cl₂ / 0 °C

With sodium azide; TEA; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.05.066