(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol

Base Information

Chemical Name:(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol
CAS No.:465520-07-4
Molecular Formula:C₂₀H₂₂FN₃O₃
Molecular Weight:371.411
Hs Code.:

Synonyms:(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol

Suppliers and Price of (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol

Chemical Property:

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Technology Process of (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol

There total 5 articles about (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.86%

: 60456-26-0
(R)-glycidyl butyrate

: 556801-41-3
N-benzyloxycarbonyl-3-fluoro-4-(4-phenylpiperazinyl)aniline

: 465520-07-4
(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol

Guidance literature:: With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; hexane; at -61 - 95 ℃; for 1h; Inert atmosphere;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 465520-07-4
(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-diisopropylethylamine

2.1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran

3.1: NaHCO₃

4.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

4.2: hexane; tetrahydrofuran / -78 - 20 °C

With n-butyllithium; ammonium formate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/S0960-894X(02)00043-4

Reference yield:

: 92-54-6
4-phenyl-1-piperazine

: 465520-07-4
(R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-diisopropylethylamine

2.1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran

3.1: NaHCO₃

4.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

4.2: hexane; tetrahydrofuran / -78 - 20 °C

With n-butyllithium; ammonium formate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/S0960-894X(02)00043-4