methyl N-(benzyloxycarbonyl)-S-triphenylmethyl-(R)-cysteinyl-(S)-allylglycinate

Base Information

Chemical Name:methyl N-(benzyloxycarbonyl)-S-triphenylmethyl-(R)-cysteinyl-(S)-allylglycinate
CAS No.:488862-45-9
Molecular Formula:C₃₆H₃₆N₂O₅S
Molecular Weight:608.758
Hs Code.:

Synonyms:methyl N-(benzyloxycarbonyl)-S-triphenylmethyl-(R)-cysteinyl-(S)-allylglycinate

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Chemical Property of methyl N-(benzyloxycarbonyl)-S-triphenylmethyl-(R)-cysteinyl-(S)-allylglycinate

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Technology Process of methyl N-(benzyloxycarbonyl)-S-triphenylmethyl-(R)-cysteinyl-(S)-allylglycinate

There total 1 articles about methyl N-(benzyloxycarbonyl)-S-triphenylmethyl-(R)-cysteinyl-(S)-allylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 26311-04-6
N-benzyloxycarbonyl-S-trityl-L-cysteine

: 173723-62-1,217440-34-1
(S)-allylglycine methyl ester hydrochloride

: 488862-45-9
methyl N-(benzyloxycarbonyl)-S-triphenylmethyl-(R)-cysteinyl-(S)-allylglycinate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; cooling;
DOI:10.1021/jo061692y

Reference yield: 86.0%

: 201230-82-2
carbon monoxide

: 488862-45-9
methyl N-(benzyloxycarbonyl)-S-triphenylmethyl-(R)-cysteinyl-(S)-allylglycinate

: 919487-84-6
N-benzyloxycarbonyl-S-trityl-(R)-cysteinyl-(S)-6-oxonorleucine methyl ester

Guidance literature:: With hydrogen; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); acetylacetonatodicarbonylrhodium(l); In methanol; at 65 ℃; for 20h; under 3040 Torr;
DOI:10.1021/jo061692y

Reference yield:

: 488862-45-9
methyl N-(benzyloxycarbonyl)-S-triphenylmethyl-(R)-cysteinyl-(S)-allylglycinate

: methyl (3R,6S,10S)-1-aza-2-oxo-3-benzyloxycarbonylamino-5-thiabicyclo[4.4.0]decane-10-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / hydrogen; BIPHEPHOS / Rh(acac)(CO)2 / methanol / 20 h / 65 °C / 3040 Torr

2: 89 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

With hydrogen; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); trifluoroacetic acid; acetylacetonatodicarbonylrhodium(l); In methanol; dichloromethane;
DOI:10.1021/jo061692y