1-[5-hydroxy-2-[[[2-(1H-pyrazol-4-yl)-4-thiazolyl]carbonyl]amino]phenyl]-4-(methylamino)-4-piperidinecarboxamide

Base Information

Chemical Name:1-[5-hydroxy-2-[[[2-(1H-pyrazol-4-yl)-4-thiazolyl]carbonyl]amino]phenyl]-4-(methylamino)-4-piperidinecarboxamide
CAS No.:1374112-89-6
Molecular Formula:C₂₀H₂₃N₇O₃S
Molecular Weight:441.514
Hs Code.:

Synonyms:1-[5-hydroxy-2-[[[2-(1H-pyrazol-4-yl)-4-thiazolyl]carbonyl]amino]phenyl]-4-(methylamino)-4-piperidinecarboxamide

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Chemical Property of 1-[5-hydroxy-2-[[[2-(1H-pyrazol-4-yl)-4-thiazolyl]carbonyl]amino]phenyl]-4-(methylamino)-4-piperidinecarboxamide

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Technology Process of 1-[5-hydroxy-2-[[[2-(1H-pyrazol-4-yl)-4-thiazolyl]carbonyl]amino]phenyl]-4-(methylamino)-4-piperidinecarboxamide

There total 6 articles about 1-[5-hydroxy-2-[[[2-(1H-pyrazol-4-yl)-4-thiazolyl]carbonyl]amino]phenyl]-4-(methylamino)-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 1374113-36-6
C₂₃H₃₄BrN₅O₃SSi

: 1374112-89-6
1-[5-hydroxy-2-[[[2-(1H-pyrazol-4-yl)-4-thiazolyl]carbonyl]amino]phenyl]-4-(methylamino)-4-piperidinecarboxamide

Guidance literature:: pyrazole-4-boronic acid pinacol ester; C₂₃H₃₄BrN₅O₃SSi; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 90 ℃; Inert atmosphere; sealed tube;

With hydrogenchloride; In 1,4-dioxane; methanol; ethanol; water; toluene; at 20 ℃;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 84100-51-6
4-methylamino-piperidine-4-carboxylic acid amide

: 1374112-89-6
1-[5-hydroxy-2-[[[2-(1H-pyrazol-4-yl)-4-thiazolyl]carbonyl]amino]phenyl]-4-(methylamino)-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 3 h / 90 °C

2.1: triethylamine / tetrahydrofuran / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 90 °C / Inert atmosphere; sealed tube

5.2: 20 °C

With hydrogen; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1374113-51-5
C₁₉H₃₄N₄O₂Si

: 1374112-89-6
1-[5-hydroxy-2-[[[2-(1H-pyrazol-4-yl)-4-thiazolyl]carbonyl]amino]phenyl]-4-(methylamino)-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 90 °C / Inert atmosphere; sealed tube

2.2: 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; toluene;