3-benzyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine

Base Information

• Chemical Name: 3-benzyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine
• CAS No.: 669056-37-5
• Molecular Formula: C₃₉H₄₃N₅O₃S
• Molecular Weight: 661.868

Synonyms:3-benzyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine

Chemical Property of 3-benzyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine

There total 7 articles about 3-benzyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-benzyloxy-estra-1,3,5(10),16-tetraeno[17,16-e]-2'-(N-tert-butoxycarbonyl-glycyl-S-benzyl-L-cysteinylamino)pyrimidine (669056-36-4) → 3-benzyloxy-estra-1,3,5(10),16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine (669056-37-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/S0039-128X(03)00145-4

Reference yield:

Estrone (53-16-7) → 3-benzyloxy-estra-1,3,5(10),16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine (669056-37-5)

Guidance literature:

Multi-step reaction with 8 steps

1: NaH / dimethylformamide

2: 97 percent / sodium methoxide / toluene

3: 77 percent / benzene / Heating

4: 86 percent / NaOMe / propan-1-ol / 70 h / 80 - 90 °C

5: 43 percent / DCC / CH₂Cl₂ / 7 h / 20 °C

6: 95 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

7: 61 percent / DCC / CH₂Cl₂ / 4 h / 20 °C

8: 89 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

With sodium methylate; sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In propan-1-ol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1016/S0039-128X(03)00145-4

Reference yield:

3-benzyloxyestra-1,3,5(10)-trien-17-one (858-98-0) → 3-benzyloxy-estra-1,3,5(10),16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine (669056-37-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 97 percent / sodium methoxide / toluene

2: 77 percent / benzene / Heating

3: 86 percent / NaOMe / propan-1-ol / 70 h / 80 - 90 °C

4: 43 percent / DCC / CH₂Cl₂ / 7 h / 20 °C

5: 95 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

6: 61 percent / DCC / CH₂Cl₂ / 4 h / 20 °C

7: 89 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

With sodium methylate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In propan-1-ol; dichloromethane; toluene; benzene;

DOI:10.1016/S0039-128X(03)00145-4

upstream raw materials:

3-benzyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(N-tert-butoxycarbonyl-glycyl-S-benzyl-L-cysteinylamino)pyrimidine

Estrone

3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one

benzyl bromide

Downstream raw materials:

3-benzyloxyestra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(O-benzyl-N-tert-butoxycarbonyl-L-serinyl-glycyl-S-benzyl-L-cysteinylamino)pyrimidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 669056-37-5 3-benzyloxy-estra-1,3,5⁽¹⁰⁾,16-tetraeno[17,16-e]-2'-(glycyl-S-benzyl-L-cysteinylamino)pyrimidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send