1-N-Boc-2-Benzylpiperazine

Base Information

• Chemical Name: 1-N-Boc-2-Benzylpiperazine
• CAS No.: 481038-63-5
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.379
• Hs Code.: 2933599090
• Mol file: 481038-63-5.mol

Synonyms:2-Benzyl-piperazine-1-carboxylicacid tert-butyl ester;tert-Butyl 2-benzylpiperazine-1-carboxylate;N-Boc-2-Benzylpiperazine;

Chemical Property of 1-N-Boc-2-Benzylpiperazine

Chemical Property:

• Vapor Pressure: 4.58E-06mmHg at 25°C
• Refractive Index: 1.524
• Boiling Point: 382.9 °C at 760 mmHg
• PKA: 8.45±0.40(Predicted)
• Flash Point: 185.4 °C
• PSA: 41.57000
• Density: 1.066 g/cm³
• LogP: 2.70470
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl2-benzylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 2-benzylpiperazine-1-carboxylate is one of the reactants for preparation of 1-?(4-?aryl-?3-?aminobutanoyl)?piperazines as dipeptidyl peptidase inhibitors for the treatment of diabetes mellitus.

Technology Process of 1-N-Boc-2-Benzylpiperazine

There total 7 articles about 1-N-Boc-2-Benzylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-tert-butyl 2,4-dibenzylpiperazine-1-carboxylate → tert-butyl (S)-2-benzylpiperazine-1-carboxylate (169447-86-3,481038-63-5)

Guidance literature:

With palladium 10% on activated carbon; In methanol; at 20 ℃; for 12h;

DOI:10.1039/c7nj04039c

Reference yield: 96.0%

→ (R)-1-Boc-2-benzylpiperazine (947684-78-8,481038-63-5)

Guidance literature:

Reference yield:

1-tert-Butoxycarbonyl-2(S)-(S),4-dibenzylpiperazine (489437-72-1) → tert-butyl (S)-2-benzylpiperazine-1-carboxylate (169447-86-3,481038-63-5)

Guidance literature:

palladium;

upstream raw materials:

1-tert-Butoxycarbonyl-2(S)-(S),4-dibenzylpiperazine

N-tert-butoxycarbonyl-L-phenylalanine

(3S)-1,3-dibenzylpiperazine-2,5-dione

(3S)-1,3-dibenzylpiperazine

Downstream raw materials:

2-[(S)-4-Boc-3-benzylpiperazinyl]-6-[3-methyl-1-(2-(trimethylsilyl)ethoxymethyl)-1H-indazol-5-yl]pyrazine

2-amino-3-[(S)-4-Boc-3-benzylpiperazinyl]-5-(3-methyl-1H-indazol-5-yl)pyrazine

Refernces

• 1、 -. "Therapeutic Piperazines". Page/Page column 12. . Retrieved 2010/11/28.
• 2、 -. "Inhibitors of farnesyl-protein transferase". . . Retrieved 2008/06/13.