Technology Process of (S)-8-(benzyloxymethyl)-1,2,3,8a-tetrahydroindolizin-5(6H)-one
There total 10 articles about (S)-8-(benzyloxymethyl)-1,2,3,8a-tetrahydroindolizin-5(6H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: di(n-butyl)tin oxide / toluene / 8 h / 80 °C / Inert atmosphere
1.2: 16 h / 80 °C / Inert atmosphere
2.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide / water; ethyl acetate; toluene / 1 h / 0 °C
3.1: tetrahydrofuran / 4 h / -10 °C
4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C
4.2: pH 7
5.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere
5.2: 3 h / 0 °C / Inert atmosphere
6.1: Grubbs catalyst first generation / dichloromethane / 6 h / 50 °C
With
4-methyl-morpholine; Grubbs catalyst first generation; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; chloroformic acid ethyl ester; di(n-butyl)tin oxide; sodium hydrogencarbonate; trifluoroacetic acid; sodium bromide;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
3.1: Wittig reaction;
DOI:10.1016/j.tetasy.2011.03.009
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide / water; ethyl acetate; toluene / 1 h / 0 °C
2.1: tetrahydrofuran / 4 h / -10 °C
3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C
3.2: pH 7
4.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere
4.2: 3 h / 0 °C / Inert atmosphere
5.1: Grubbs catalyst first generation / dichloromethane / 6 h / 50 °C
With
4-methyl-morpholine; Grubbs catalyst first generation; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; chloroformic acid ethyl ester; sodium hydrogencarbonate; trifluoroacetic acid; sodium bromide;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
2.1: Wittig reaction;
DOI:10.1016/j.tetasy.2011.03.009
