Technology Process of 1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine hydrochloride
There total 1 articles about 1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-tert-butoxycarbonyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine; 4-iodobenzoic acid;
With
potassium carbonate;
copper(l) iodide; dimethylaminoacetic acid;
In
dimethyl sulfoxide;
at 130 ℃;
for 4h;
With
hydrogenchloride;
In
dichloromethane; water; dimethyl sulfoxide;
pH=3;
pyrrolidine;
With
HATU; trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 24.17h;
