4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}

Base Information

Chemical Name:4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}
CAS No.:1370259-80-5
Molecular Formula:C₂₉H₄₂F₂N₆O
Molecular Weight:528.689
Hs Code.:

Synonyms:4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}

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Chemical Property of 4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}

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Technology Process of 4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}

There total 11 articles about 4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1370259-90-7
(4-{1-(4,4-difluorocyclohexylcarbonylamino)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester

: 1370259-80-5
4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.75h; Cooling with ice;
DOI:10.1039/c2ob06801j

Reference yield:

: 423165-07-5
UK-408027

: 1370259-80-5
4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.25 h / Inert atmosphere; Cooling with ice; Molecular sieve

1.2: 4 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: palladium 10% on activated carbon; hydrogen / methanol / 96 h / 20 °C / 3102.97 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.25 h / 20 °C / Cooling with ice

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.25 h / Inert atmosphere; Cooling with ice; Molecular sieve

4.2: 4 h / 20 °C / Inert atmosphere; Molecular sieve

5.1: trifluoroacetic acid / dichloromethane / 1.75 h / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c2ob06801j

Reference yield:

: 3-(4-aminophenyl)acrylic acid isopropyl ester

: 1370259-80-5
4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 2 h / -78 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; water / 48 h / Reflux

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.25 h / Inert atmosphere; Cooling with ice; Molecular sieve

4.2: 4 h / 20 °C / Inert atmosphere; Molecular sieve

5.1: palladium 10% on activated carbon; hydrogen / methanol / 96 h / 20 °C / 3102.97 Torr

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.25 h / 20 °C / Cooling with ice

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.25 h / Inert atmosphere; Cooling with ice; Molecular sieve

7.2: 4 h / 20 °C / Inert atmosphere; Molecular sieve

8.1: trifluoroacetic acid / dichloromethane / 1.75 h / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; n-butyllithium; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1039/c2ob06801j