N-(phenyl)-N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-4-methoxybenzamide

Base Information

Chemical Name:N-(phenyl)-N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-4-methoxybenzamide
CAS No.:293743-68-7
Molecular Formula:C₂₃H₂₀F₃NO₃
Molecular Weight:415.412
Hs Code.:

Synonyms:N-(phenyl)-N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-4-methoxybenzamide

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Chemical Property of N-(phenyl)-N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-4-methoxybenzamide

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Technology Process of N-(phenyl)-N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-4-methoxybenzamide

There total 6 articles about N-(phenyl)-N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 100-07-2
4-methoxy-benzoyl chloride

: 243121-52-0
N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-aniline

: 293743-68-7
N-(phenyl)-N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-4-methoxybenzamide

Guidance literature:: With potassium carbonate; In 1,2-dichloro-benzene; at 120 - 150 ℃; for 16h;
DOI:10.1016/S0968-0896(00)00075-4

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 293743-68-7
N-(phenyl)-N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Mg turnings / tetrahydrofuran

1.2: 72 percent / tetrahydrofuran / 2 h

2.1: benzene / Heating

3.1: 80 percent / LiAlH₄ / diethyl ether / 2 h / Heating

4.1: 51 percent / K₂CO₃ / 1,2-dichloro-benzene / 16 h / 120 - 150 °C

With lithium aluminium tetrahydride; potassium carbonate; magnesium; In tetrahydrofuran; diethyl ether; 1,2-dichloro-benzene; benzene; 1.1: Metallation / 1.2: Acylation / 2.1: Staudinger reaction / 3.1: Reduction / 4.1: Acylation;
DOI:10.1016/S0968-0896(00)00075-4

Reference yield:

: 30724-22-2
2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone

: 293743-68-7
N-(phenyl)-N-[1,1,1-trifluoro-2-(3-methoxy)-phenethyl]-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzene / Heating

2: 80 percent / LiAlH₄ / diethyl ether / 2 h / Heating

3: 51 percent / K₂CO₃ / 1,2-dichloro-benzene / 16 h / 120 - 150 °C

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; 1,2-dichloro-benzene; benzene; 1: Staudinger reaction / 2: Reduction / 3: Acylation;
DOI:10.1016/S0968-0896(00)00075-4