2-[1-(2-phenylethyl)piperidin-4-ylcarbonyl]-3,4-dihydro-1-hydroxynaphthalene

Base Information

• Chemical Name: 2-[1-(2-phenylethyl)piperidin-4-ylcarbonyl]-3,4-dihydro-1-hydroxynaphthalene
• CAS No.: 156544-93-3
• Molecular Formula: C₂₄H₂₇NO₂
• Molecular Weight: 361.484
• Mol file: 156544-93-3.mol

Synonyms:2-[1-(2-phenylethyl)piperidin-4-ylcarbonyl]-3,4-dihydro-1-hydroxynaphthalene

Chemical Property of 2-[1-(2-phenylethyl)piperidin-4-ylcarbonyl]-3,4-dihydro-1-hydroxynaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-(2-phenylethyl)piperidin-4-ylcarbonyl]-3,4-dihydro-1-hydroxynaphthalene

There total 4 articles about 2-[1-(2-phenylethyl)piperidin-4-ylcarbonyl]-3,4-dihydro-1-hydroxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-phenyl-2-bromoethane (103-63-9) + (1-Hydroxy-3,4-dihydro-naphthalen-2-yl)-piperidin-4-yl-methanone; hydrochloride → 2-[1-(2-phenylethyl)piperidin-4-ylcarbonyl]-3,4-dihydro-1-hydroxynaphthalene (156544-93-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; 1.) room temperature, 3 d, 2.) 70 deg C, 17 h;

DOI:10.1016/S0968-0896(98)00028-5

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → 2-[1-(2-phenylethyl)piperidin-4-ylcarbonyl]-3,4-dihydro-1-hydroxynaphthalene (156544-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N,N-carbodiimidazole, 2.) LDA, 3.) HCl / 1.) room temperature, 45 min, 2.) THF, -78 deg C, 40 min; warm to room temperature, 3.) EtOAc

2: 47 percent / i-Pr₂NEt / dimethylformamide / 1.) room temperature, 3 d, 2.) 70 deg C, 17 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(98)00028-5

Reference yield:

3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 2-[1-(2-phenylethyl)piperidin-4-ylcarbonyl]-3,4-dihydro-1-hydroxynaphthalene (156544-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N,N-carbodiimidazole, 2.) LDA, 3.) HCl / 1.) room temperature, 45 min, 2.) THF, -78 deg C, 40 min; warm to room temperature, 3.) EtOAc

2: 47 percent / i-Pr₂NEt / dimethylformamide / 1.) room temperature, 3 d, 2.) 70 deg C, 17 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(98)00028-5

upstream raw materials:

1-phenyl-2-bromoethane

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

3,4-dihydronaphthalene-1(2H)-one