2-allyl-4-(3,4-difluorobenzyl)-2-naphthalen-2-ylmethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-allyl-4-(3,4-difluorobenzyl)-2-naphthalen-2-ylmethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:880169-77-7
Molecular Formula:C₃₀H₃₂F₂N₂O₃
Molecular Weight:506.592
Hs Code.:

Synonyms:2-allyl-4-(3,4-difluorobenzyl)-2-naphthalen-2-ylmethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2-allyl-4-(3,4-difluorobenzyl)-2-naphthalen-2-ylmethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-allyl-4-(3,4-difluorobenzyl)-2-naphthalen-2-ylmethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

There total 4 articles about 2-allyl-4-(3,4-difluorobenzyl)-2-naphthalen-2-ylmethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 880169-76-6
2-allyl-4-(3,4-difluorobenzyl)-5-oxo-piperazine-1-carboxylic acid tert-butyl ester

: 939-26-4
2-bromomethylnaphthyl bromide

: 880169-77-7
2-allyl-4-(3,4-difluorobenzyl)-2-naphthalen-2-ylmethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: 2-allyl-4-(3,4-difluorobenzyl)-5-oxo-piperazine-1-carboxylic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

2-bromomethylnaphthyl bromide; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1080/00397910500383550

Reference yield:

: 880169-75-5
{1-[(3,4-difluorobenzylamino)-methyl]-but-3-enyl}-carbamic acid tert-butyl ester

: 880169-77-7
2-allyl-4-(3,4-difluorobenzyl)-2-naphthalen-2-ylmethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogen carbonate; water / ethyl acetate / 0.33 h / 0 °C

1.2: 93 percent / Cs₂CO₃ / dimethylformamide / 2 h / 65 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.33 h / -78 °C

2.2: 69 percent / tetrahydrofuran / 2 h / -78 °C

With water; sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate;
DOI:10.1080/00397910500383550

Reference yield:

: 72235-53-1
3,4-difluorobenzylamine

: 880169-77-7
2-allyl-4-(3,4-difluorobenzyl)-2-naphthalen-2-ylmethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / sodium triacetoxyborohydride; molecular sieves 4 Angstroem / 1,2-dichloro-ethane / 14 h / 20 °C

2.1: sodium hydrogen carbonate; water / ethyl acetate / 0.33 h / 0 °C

2.2: 93 percent / Cs₂CO₃ / dimethylformamide / 2 h / 65 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.33 h / -78 °C

3.2: 69 percent / tetrahydrofuran / 2 h / -78 °C

With 4 A molecular sieve; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1080/00397910500383550