(1R)-(+)-(1,3,5/2,4)-2,3,4,5-tetrahydroxycyclohexane-1-methanol penta-acetate

Base Information

• Chemical Name: (1R)-(+)-(1,3,5/2,4)-2,3,4,5-tetrahydroxycyclohexane-1-methanol penta-acetate
• CAS No.: 90695-22-0
• Molecular Formula: C₁₇H₂₄O₁₀
• Molecular Weight: 388.372
• Mol file: 90695-22-0.mol

Synonyms:(1R)-(+)-(1,3,5/2,4)-2,3,4,5-tetrahydroxycyclohexane-1-methanol penta-acetate

Chemical Property of (1R)-(+)-(1,3,5/2,4)-2,3,4,5-tetrahydroxycyclohexane-1-methanol penta-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-(+)-(1,3,5/2,4)-2,3,4,5-tetrahydroxycyclohexane-1-methanol penta-acetate

There total 106 articles about (1R)-(+)-(1,3,5/2,4)-2,3,4,5-tetrahydroxycyclohexane-1-methanol penta-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic anhydride (108-24-7) + (+/-)-2exo,3exo-diacetoxy-5endo-acxetoxymethyl-7-oxabicyclo<2.2.1>heptane (64589-25-9,90695-20-8,117772-63-1,117772-66-4) → DL-(1,2,3,4/5)-5-acethoxymethyl-1,2,3,4-tetra-O-acetyl-1,2,3,4-cyclohexanetetrol (10226-79-6,16656-57-8,16802-99-6,52079-86-4,60594-30-1,60594-31-2,64625-67-8,74560-70-6,74561-02-7,74561-06-1,74561-11-8,77209-45-1,90694-06-7,90695-22-0,94943-06-3,94943-07-4,97372-12-8,97372-20-8,97372-27-5,97372-29-7,102629-12-9,105017-73-0,105017-80-9,105368-83-0,108813-47-4,108813-49-6,108866-23-5,115184-61-7,115184-64-0)

Guidance literature:

With sulfuric acid; In acetic acid; at 90 ℃; for 45h;

DOI:10.1016/0008-6215(88)85054-7

Reference yield: 90.0%

acetic anhydride (108-24-7) + (1R,2R,3S,4R,5R)-5-Hydroxymethyl-cyclohexane-1,2,3,4-tetraol (10226-73-0,16656-62-5,16802-98-5,52079-85-3,64625-68-9,74560-71-7,74561-03-8,74561-07-2,74561-10-7,86117-80-8,86117-81-9,86117-82-0,90694-07-8,94943-08-5,94943-09-6,95043-48-4,96647-89-1,97372-13-9,97372-19-5,97372-28-6,97372-30-0,102629-13-0,105017-74-1,105017-81-0,108867-09-0,109668-67-9,135820-00-7) → DL-(1,2,3,5/4)-5-acethoxymethyl-1,2,3,4-tetra-O-acetyl-1,2,3,4-cyclohexanetetrol (10226-79-6,16656-57-8,16802-99-6,52079-86-4,60594-30-1,60594-31-2,64625-67-8,74560-70-6,74561-02-7,74561-06-1,74561-11-8,77209-45-1,90694-06-7,90695-22-0,94943-06-3,94943-07-4,97372-12-8,97372-20-8,97372-27-5,97372-29-7,102629-12-9,105017-73-0,105017-80-9,105368-83-0,108813-47-4,108813-49-6,108866-23-5,115184-61-7,115184-64-0)

Guidance literature:

With pyridine; In acetic acid; Ambient temperature;

DOI:10.1246/bcsj.53.1121

Reference yield: 66.0%

acetic anhydride (108-24-7) + (1RS,2SR,3SR,4SR,5RS)-2,3,4-triacetoxy-6-oxabicyclo<3.2.1>octane (108794-46-3) → DL-(1,3,4,5/2)-1,2,3,4-tetra-acetoxy-5-acetoxymethylcyclohexane (10226-79-6,16656-57-8,16802-99-6,52079-86-4,60594-30-1,60594-31-2,64625-67-8,74560-70-6,74561-02-7,74561-06-1,74561-11-8,77209-45-1,90694-06-7,90695-22-0,94943-06-3,94943-07-4,97372-12-8,97372-20-8,97372-27-5,97372-29-7,102629-12-9,105017-73-0,105017-80-9,105368-83-0,108813-47-4,108813-49-6,108866-23-5,115184-61-7,115184-64-0)

Guidance literature:

With sulfuric acid; acetic acid; at 50 ℃; for 48h;

DOI:10.1016/S0008-6215(00)90192-7

upstream raw materials:

acetic anhydride

(1S)-2-exo,3-endo-diacetoxy-5-endo-acetoxymethyl-7-oxabicyclo<2.2.1.>heptane

1L-(1,3,5/2,4)-2,3,4-Tri-O-benzyl-5-C-hydroxymethyl-1,2,3,4-cyclohexantetrol

2,3,4,6-tetra-O-acetyl-1-deoxy-1-methylene-5a-carba-D-glucopyranose

Downstream raw materials:

Pseudo-α-DL-talopyranose; 2c,3c,4c,5t-Tetrahydroxy-1-cyclohexan-methanol

(+/-)-1r-Triphenylmethoxymethyl-2c,3c,4c,5t-tetraacetoxy-cyclohexan

DL-(1,2/3,4,5)-5-hydroxymethyl-1,2,3,4-cyclohexanetetrol

(1SR,3SR,5SR,8RS,10SR,12RS)-5,12-diphenyl-4,6,11,13-tetraoxatricyclo<8.3.0.0^3,8>tridecan-2-one