beta-Amyloid (1-42) human

Base Information

• Chemical Name: beta-Amyloid (1-42) human
• CAS No.: 107761-42-2
• Molecular Formula: C203H311N55O60S
• Molecular Weight: 4514.04
• Hs Code.: 29332900
• Mol file: 107761-42-2.mol

Synonyms:Amyloid b 1-42;Amyloid, b- (1-42);Ab1-42;abeta 1-42;Peptide b (human amyloid);

Chemical Property of beta-Amyloid (1-42) human

Chemical Property:

• PSA: 1840.49000
• LogP: 1.35150
• Storage Temp.: −20°C
• Solubility.: Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO.

Purity/Quality:

99% ,99.9%, ^*data from raw suppliers

β-Amyloid 1-42, Human ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer?s disease and neurodegeneration.

Refernces

Piperidine-derived γ-secretase modulators

10.1016/j.bmcl.2009.08.072

The study focuses on the structure-activity relationship (SAR) of a novel series of piperidine-derived c-secretase modulators for the potential treatment of Alzheimer's disease (AD). The research identifies compound 10h as a potent modulator that selectively decreases Ab42 levels, increases Ab38 levels, and does not affect Ab40 levels in vitro. This compound also exhibits favorable pharmacokinetic properties in mice, rats, and dogs, along with good central nervous system (CNS) penetration in mice. The study aims to develop more potent c-secretase modulators that could slow or halt AD progression without the side effects associated with inhibitors, by modulating the enzyme's action to produce less pathogenic peptides.