CAS No.107761-42-2,beta-Amyloid (1-42) human Suppliers

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Basic Information

Molecular Structure:
CAS No.:	107761-42-2
Name:	beta-Amyloid (1-42) human

Formula:	C₂₀₃H₃₁₁N₅₅O₆₀S
Molecular Weight:	4514.04
Synonyms:	Amyloid b 1-42;Amyloid, b- (1-42);Ab1-42;abeta 1-42;Peptide b (human amyloid);
Safety:	24/25
PSA:	1840.49000
LogP:	1.35150

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Chemistry

The Molecular Structure of Beta-Amyloid (1-42) human (CAS NO.107761-42-2):

Molecular Formula: C₂₀₃H₃₁₁N₅₅O₆₀S
Molecular Weight: 4514.04
Product Categories: Peptide;Amyloid beta Protein Fragments;Amyloid β Protein FragmentsNeuropeptides;Alzheimers and Neurodegenerative Disease Research;Neurodegenerative Disease Peptides;β Amyloid Peptides;Amyloid beta-peptide and related;Signalling
Storage temp: −20°C
Solubility: insoluble in water, may be dissolved in any buffer with pH greater than 9
Synonyms: L-alpha-Aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-serylglycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine

Safety Profile

WGK Germany: 3

Specification

This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the ‘longer forms’ of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors.