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| CAS No.: | 107761-42-2 |
|---|---|
| Name: | beta-Amyloid (1-42) human |
| Molecular Structure: | |
|
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| Formula: | C203H311N55O60S |
| Molecular Weight: | 4514.04 |
| Synonyms: | Amyloid b 1-42;Amyloid, b- (1-42);Ab1-42;abeta 1-42;Peptide b (human amyloid); |
| Safety: | 24/25 |
| PSA: | 1840.49000 |
| LogP: | 1.35150 |
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Chemistry
The Molecular Structure of Beta-Amyloid (1-42) human (CAS NO.107761-42-2):
Molecular Formula: C203H311N55O60S
Molecular Weight: 4514.04
Product Categories: Peptide;Amyloid beta Protein Fragments;Amyloid β Protein FragmentsNeuropeptides;Alzheimers and Neurodegenerative Disease Research;Neurodegenerative Disease Peptides;β Amyloid Peptides;Amyloid beta-peptide and related;Signalling
Storage temp: −20°C
Solubility: insoluble in water, may be dissolved in any buffer with pH greater than 9
Synonyms: L-alpha-Aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-serylglycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine
Safety Profile
WGK Germany: 3
Specification
This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the ‘longer forms’ of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors.