N-(3-(6-chloro-5-cyano-4-(4-phenoxyphenyl)pyridin-2-yl)phenyl)acetamide

Base Information

Chemical Name:N-(3-(6-chloro-5-cyano-4-(4-phenoxyphenyl)pyridin-2-yl)phenyl)acetamide
CAS No.:1266161-04-9
Molecular Formula:C₂₆H₁₈ClN₃O₂
Molecular Weight:439.901
Hs Code.:

Synonyms:N-(3-(6-chloro-5-cyano-4-(4-phenoxyphenyl)pyridin-2-yl)phenyl)acetamide

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Chemical Property of N-(3-(6-chloro-5-cyano-4-(4-phenoxyphenyl)pyridin-2-yl)phenyl)acetamide

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Technology Process of N-(3-(6-chloro-5-cyano-4-(4-phenoxyphenyl)pyridin-2-yl)phenyl)acetamide

There total 3 articles about N-(3-(6-chloro-5-cyano-4-(4-phenoxyphenyl)pyridin-2-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1266160-98-8
2,6-dichloro-4-(4-phenoxyphenyl)nicotinonitrile

: 78887-39-5
3-Acetamidophenylboronic acid

: 1266161-04-9
N-(3-(6-chloro-5-cyano-4-(4-phenoxyphenyl)pyridin-2-yl)phenyl)acetamide

Guidance literature:: With potassium phosphate monohydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 67-36-7
4-phenoxy benzaldehyde

: 1266161-04-9
N-(3-(6-chloro-5-cyano-4-(4-phenoxyphenyl)pyridin-2-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / 15 h / 20 °C

2: trichlorophosphate / 24 h / 135 °C

3: potassium phosphate monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

With potassium phosphate monohydrate; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; N,N-dimethyl-formamide; 3: Suzuki Coupling;

Reference yield:

: trans-3-cyano-6-oxo-4-(4-phenoxyphenyl)-5-(pyridinium-1-yl)-1,4,5,6-tetrahydropyridin-2-olate

: 1266161-04-9
N-(3-(6-chloro-5-cyano-4-(4-phenoxyphenyl)pyridin-2-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 24 h / 135 °C

2: potassium phosphate monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

With potassium phosphate monohydrate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; 2: Suzuki Coupling;