[D₇]-5-((2-((3-methoxy-4,5-dimethylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one

Base Information

• Chemical Name: [D₇]-5-((2-((3-methoxy-4,5-dimethylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one
• CAS No.: 1357103-03-7
• Molecular Formula: C₂₁H₂₁N₅O₃
• Molecular Weight: 398.374

Synonyms:[D₇]-5-((2-((3-methoxy-4,5-dimethylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one

Chemical Property of [D₇]-5-((2-((3-methoxy-4,5-dimethylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one

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Technology Process of [D₇]-5-((2-((3-methoxy-4,5-dimethylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one

There total 5 articles about [D₇]-5-((2-((3-methoxy-4,5-dimethylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

[D4]-5-((2-chloro-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one + [D3]-3-methoxy-4,5-dimethylaniline·HBr → [D7]-5-((2-((3-methoxy-4,5-dimethylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one (1357103-03-7)

Guidance literature:

With trifluoroacetic acid; In isopropyl alcohol; at 100 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2019.02.059

Reference yield:

C8H7Br2NO3 → [D7]-5-((2-((3-methoxy-4,5-dimethylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one (1357103-03-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 40 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 21 h / 4137.29 Torr

3: trifluoroacetic acid / isopropyl alcohol / 100 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; trifluoroacetic acid; In methanol; isopropyl alcohol; acetonitrile;

DOI:10.1016/j.tet.2019.02.059

Reference yield:

thymine-α,α,α,6-d4 (156054-85-2) → [D7]-5-((2-((3-methoxy-4,5-dimethylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one (1357103-03-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / 130 °C / Sealed tube; Inert atmosphere

2: sodium hydrogencarbonate / methanol; water / 24 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / isopropyl alcohol / 100 °C / Inert atmosphere

With sodium hydrogencarbonate; trifluoroacetic acid; trichlorophosphate; In methanol; water; isopropyl alcohol;

DOI:10.1016/j.tet.2019.02.059

upstream raw materials:

[D₄]-2,4-dichloro-5-methylpyrimidine

thymine-α,α,α,6-d4

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