(Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH

Base Information

Chemical Name:(Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH
CAS No.:713122-18-0
Molecular Formula:C₆₂H₈₄N₁₀O₁₉S₂
Molecular Weight:1337.54
Hs Code.:

Synonyms:(Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH

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Chemical Property of (Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH

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Technology Process of (Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH

There total 19 articles about (Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 713122-17-9
(Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OTce

: 713122-18-0
(Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH

Guidance literature:: With acetic acid; zinc; at 0 ℃; for 2.5h;
DOI:10.1021/jo0496805

Reference yield:

: 65806-90-8
(R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)propanoic acid

: 713122-18-0
(Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH

Guidance literature:: Multi-step reaction with 10 steps

1: 78 percent / pyridine; HOBt; DCC / 18 h / 0 °C

2: 76 percent / TFA / 0.75 h / 10 °C

3: 88 percent / pyridine; HOBt; DCC / 18 h / 0 °C

4: TFA / 0.5 h / 25 °C

5: 3.80 g / HOAt; EDCI / CH₂Cl₂ / 18 h / 0 °C

6: TFA / 0.5 h / 25 °C

7: 3.18 g / HOAt; EDCI / CH₂Cl₂ / 16 h / 0 °C

8: TFA / 0.5 h / 25 °C

9: 52 percent / HOAt; EDCI / CH₂Cl₂ / 18 h / 0 °C

10: 94 percent / aq. AcOH; Zn powder / 2.5 h / 0 °C

With pyridine; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In dichloromethane;
DOI:10.1021/jo0496805

Reference yield:

: 71989-33-8,128107-47-1
Nα-(9-fluorenylmethoxycarbonyl)-D-serine-tert-butyl ether

: 713122-18-0
(Z)-D-Ser{Fmoc-D-Ser[Boc-L-Ala-L-Cys(Acm)-L-Val]-L-Ala-L-Cys(Acm)-L-Val}-OH

Guidance literature:: Multi-step reaction with 10 steps

1: 66 percent / pyridine; HOBt; DCC / 18 h / 0 °C

2: 72 percent / TFA / 0.75 h / 10 °C

3: 73 percent / pyridine; HOBt; DCC / 18 h / 0 °C

4: TFA / 0.5 h / 25 °C

5: 2.06 g / HOAt; EDCI / CH₂Cl₂ / 18 h / 0 °C

6: TFA / 0.5 h / 25 °C

7: 1.41 g / HOAt; EDCI / CH₂Cl₂ / 16 h / 0 °C

8: 91 percent / aq. AcOH; Zn powder / 2.5 h / 0 °C

9: 52 percent / HOAt; EDCI / CH₂Cl₂ / 18 h / 0 °C

10: 94 percent / aq. AcOH; Zn powder / 2.5 h / 0 °C

With pyridine; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In dichloromethane;
DOI:10.1021/jo0496805