N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Base Information

Chemical Name:N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide
CAS No.:710322-32-0
Molecular Formula:C₂₅H₃₃ClN₄O₄S
Molecular Weight:521.08
Hs Code.:

Synonyms:N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

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Chemical Property of N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

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Technology Process of N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

There total 3 articles about N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 300356-14-3
(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

: 710322-31-9
1-(5-amino-pyrazin-2-yl)-ethanone O-tertbutyl-oxime

: 710322-32-0
N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Guidance literature:: (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃; for 3h;

1-(5-amino-pyrazin-2-yl)-ethanone O-tertbutyl-oxime; With 2,6-dimethylpyridine; In tetrahydrofuran; dichloromethane; at 0 - 25 ℃;

Reference yield:

: 710322-30-8
N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2,2-dimethyl-propionamide

: 710322-32-0
N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / 1,4-dioxane / 48 h / Inert atmosphere; Reflux

2: Inert atmosphere

With hydrazine hydrate; In 1,4-dioxane;
DOI:10.1021/ml400027y

Reference yield:

: 710322-29-5
N-(5-acetyl-pyrazin-2-yl)-2,2-dimethyl-propionamide

: 710322-32-0
N-[5-(1-tert-butoxyimino-ethyl)-pyrazin-2-yl]-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / methanol / 0.5 h / Inert atmosphere; Reflux

2: hydrazine hydrate / 1,4-dioxane / 48 h / Inert atmosphere; Reflux

3: Inert atmosphere

With pyridine; hydrazine hydrate; In 1,4-dioxane; methanol;
DOI:10.1021/ml400027y