(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

Base Information

• Chemical Name: (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid
• CAS No.: 300356-14-3
• Molecular Formula: C₁₅H₁₉ClO₄S
• Molecular Weight: 330.832
• Mol file: 300356-14-3.mol

Synonyms:(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

Chemical Property of (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

There total 14 articles about (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid (345635-33-8) → (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid (300356-14-3) + (S)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid (1265819-92-8)

Guidance literature:

With hydrogen; [(S)-(6,6'-dimethoxybiphenyl-2,2'-diyl)bis[bis(3,5-dimethylphenyl)-phosphineo]bisacetato]ruthenium(II); In methanol; at 50 ℃; for 17h; under 37503.8 Torr; Product distribution / selectivity; Autoclave;

Reference yield: 96.1%

(E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt (1265819-87-1) → (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid (300356-14-3)

Guidance literature:

With hydrogen; [Ir((S,S)-(3,5-Xyl-SKEWPHOS))(COD)]; In dichloromethane; water; at 50 ℃; for 18h; under 15001.5 Torr; Autoclave;

Reference yield: 92.5%

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt (1265819-85-9) → (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid (300356-14-3)

Guidance literature:

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt; With hydrogen; [Ru(OAc)2((S)-3,5-Xyl-MeOBIPHEP)]; In methanol; at 50 ℃; for 17h; under 37503.8 Torr; Autoclave;

With sulfuric acid; In methanol; Product distribution / selectivity;

upstream raw materials:

(2R)-2-[3-chloro-4-(methylsulfanyl)phenyl]-3-cyclopentylpropanoic acid

(3-chloro-4-methylsulfanyl-phenyl)-acetic acid

(3-Chloro-4-methanesulfonyl-phenyl)acetic acid

(E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt

Downstream raw materials:

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-methanesulfonylamino-pyridin-2-yl)-propionamide

N-(5-bromo-pyridin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-pyridin-2-yl-propionamide

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-quinolin-2-yl-propionamide