6-[4-(tert-butyldimethylsilyloxy)phenyl]-4-(1,3-dithiolan-2-ylmethyl)-4-[(4-methylphenyl)sulfonyl]hexan-2-one

Base Information

Chemical Name:6-[4-(tert-butyldimethylsilyloxy)phenyl]-4-(1,3-dithiolan-2-ylmethyl)-4-[(4-methylphenyl)sulfonyl]hexan-2-one
CAS No.:808739-76-6
Molecular Formula:C₂₉H₄₂O₄S₃Si
Molecular Weight:578.934
Hs Code.:

Synonyms:6-[4-(tert-butyldimethylsilyloxy)phenyl]-4-(1,3-dithiolan-2-ylmethyl)-4-[(4-methylphenyl)sulfonyl]hexan-2-one

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Chemical Property of 6-[4-(tert-butyldimethylsilyloxy)phenyl]-4-(1,3-dithiolan-2-ylmethyl)-4-[(4-methylphenyl)sulfonyl]hexan-2-one

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Technology Process of 6-[4-(tert-butyldimethylsilyloxy)phenyl]-4-(1,3-dithiolan-2-ylmethyl)-4-[(4-methylphenyl)sulfonyl]hexan-2-one

There total 6 articles about 6-[4-(tert-butyldimethylsilyloxy)phenyl]-4-(1,3-dithiolan-2-ylmethyl)-4-[(4-methylphenyl)sulfonyl]hexan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 540-63-6
ethane-1,2-dithiol

: 808739-75-5
5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(2-methyl-1,3-dioxolan-2-ylmethyl)-3-[(4-methylphenyl)sulfonyl]pentanal

: 808739-76-6
6-[4-(tert-butyldimethylsilyloxy)phenyl]-4-(1,3-dithiolan-2-ylmethyl)-4-[(4-methylphenyl)sulfonyl]hexan-2-one

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -20 ℃; for 15h;
DOI:10.1055/s-2004-831240

Reference yield:

: 147974-20-7
3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propionaldehyde

: 808739-76-6
6-[4-(tert-butyldimethylsilyloxy)phenyl]-4-(1,3-dithiolan-2-ylmethyl)-4-[(4-methylphenyl)sulfonyl]hexan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 80 percent / K₂CO₃; 18-crown-6 / toluene / 2 h / Heating

2.1: 90 percent / AcOH / ethanol / 48 h / 20 °C

3.1: 80 percent / p-TsOH / toluene / 2.5 h / Heating

4.1: t-BuLi / hexane; tetrahydrofuran / 0.33 h / 0 °C

4.2: 75 percent / hexane; tetrahydrofuran / 12 h / 20 °C

5.1: O₃ / CH₂Cl₂ / 0.17 h / -78 °C

5.2: 80 percent / AcOH; Zn / CH₂Cl₂ / 2 h / 20 °C

6.1: 55 percent / BF₃*OEt₂ / CH₂Cl₂ / 15 h / -20 °C

With 18-crown-6 ether; boron trifluoride diethyl etherate; tert.-butyl lithium; potassium carbonate; toluene-4-sulfonic acid; ozone; acetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene; 1.1: Wittig reaction;
DOI:10.1055/s-2004-831240

Reference yield:

: 808739-71-1
(3E)-6-[4-(tert-butyldimethylsilyloxy)phenyl]hex-3-en-2-one

: 808739-76-6
6-[4-(tert-butyldimethylsilyloxy)phenyl]-4-(1,3-dithiolan-2-ylmethyl)-4-[(4-methylphenyl)sulfonyl]hexan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / AcOH / ethanol / 48 h / 20 °C

2.1: 80 percent / p-TsOH / toluene / 2.5 h / Heating

3.1: t-BuLi / hexane; tetrahydrofuran / 0.33 h / 0 °C

3.2: 75 percent / hexane; tetrahydrofuran / 12 h / 20 °C

4.1: O₃ / CH₂Cl₂ / 0.17 h / -78 °C

4.2: 80 percent / AcOH; Zn / CH₂Cl₂ / 2 h / 20 °C

5.1: 55 percent / BF₃*OEt₂ / CH₂Cl₂ / 15 h / -20 °C

With boron trifluoride diethyl etherate; tert.-butyl lithium; toluene-4-sulfonic acid; ozone; acetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene;
DOI:10.1055/s-2004-831240