sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate

Base Information

• Chemical Name: sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate
• CAS No.: 851749-68-3
• Molecular Formula: C₁₂H₅F₂N₂OS*Na
• Molecular Weight: 286.237

Synonyms:sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate

Chemical Property of sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate

There total 1 articles about sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,3-dimethyluracil (874-14-6,156398-76-4) + 2,6-difluorophenylisothiocyanate (207974-17-2) + acetonitrile (75-05-8,26809-02-9) → sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate (851749-68-3)

Guidance literature:

acetonitrile; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

2,6-difluorophenylisothiocyanate; In tetrahydrofuran; at -78 - 20 ℃; for 2.08333h;

1,3-dimethyluracil; In tetrahydrofuran; ethanol; for 18h; Heating / reflux;

Reference yield: 89.0%

sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate (851749-68-3) + ethyl bromoacetate (105-36-2) → ethyl 3-amino-7-(2,6-difluorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate (1030833-75-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 50 ℃; for 1.5h;

Reference yield: 81.0%

sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate (851749-68-3) + bromonitromethane (563-70-2) → 3-amino-7-(2,6-difluorophenyl)-2-nitrothieno[2,3-b]pyridin-6(7H)-one (851749-70-7)

Guidance literature:

With potassium carbonate; In toluene; acetonitrile; at 55 ℃;

upstream raw materials:

1,3-dimethyluracil

2,6-difluorophenylisothiocyanate

acetonitrile

Downstream raw materials:

3-amino-7-(2,6-difluorophenyl)-2-nitrothieno[2,3-b]pyridin-6(7H)-one

ethyl 3-amino-7-(2,6-difluorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

3-amino-7-(2,6-difluorophenyl)-2-{[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl}thieno[2,3-b]pyridin-6(7H)-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 851749-68-3 sodium 3-cyano-1-(2, 6-difluorophenyl)-6-oxo-1,6-dihydropyridine-2-thiolate

Send

Send

Metric Ton KG G Pound L ML

Send

Send