Technology Process of tert-butyl((2S,4S)-4-methoxy-2-methyl-5-((R)-oxiran-2-yl)pentyloxy)diphenylsilane
There total 8 articles about tert-butyl((2S,4S)-4-methoxy-2-methyl-5-((R)-oxiran-2-yl)pentyloxy)diphenylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S,4S,6S)-7-(tert-butyldiphenylsilyloxy)-4-methoxy-6-methylheptane-1,2-diol;
With
2,4,6-trimethyl-pyridine; acetyl chloride;
In
dichloromethane;
at -78 ℃;
for 10.1667h;
With
dmap; methanesulfonyl chloride; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 2.16667h;
With
potassium carbonate;
In
methanol;
for 1h;
Inert atmosphere;
DOI:10.1021/jo301425c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; dmap / dichloromethane / 12 h / 0 - 20 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 10 h / 0 - 20 °C
3.1: (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; acetic acid; water / toluene / 24 h / 20 °C / Cooling with ice
4.1: copper(l) iodide / tetrahydrofuran / 0.08 h / -20 °C / Inert atmosphere
4.2: 1 h / -40 - -20 °C / Inert atmosphere
5.1: potassium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
6.1: (R,R)-Jacobsen catalyst; acetic acid; water / toluene / 24 h / 20 °C / Cooling with ice
With
dmap; copper(l) iodide; (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; (R,R)-Jacobsen catalyst; water; potassium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo301425c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; dmap / dichloromethane / 12 h / 0 - 20 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 10 h / 0 - 20 °C
3.1: (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; acetic acid; water / toluene / 24 h / 20 °C / Cooling with ice
4.1: copper(l) iodide / tetrahydrofuran / 0.08 h / -20 °C / Inert atmosphere
4.2: 1 h / -40 - -20 °C / Inert atmosphere
5.1: potassium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
6.1: (R,R)-Jacobsen catalyst; acetic acid; water / toluene / 24 h / 20 °C / Cooling with ice
With
dmap; copper(l) iodide; (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; (R,R)-Jacobsen catalyst; water; potassium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo301425c
