H-LEU-SER-P-NITRO-PHE-NLE-ALA-LEU-OME TFA

Base Information

• Chemical Name: H-LEU-SER-P-NITRO-PHE-NLE-ALA-LEU-OME TFA
• CAS No.: 99764-63-3
• Molecular Formula: C34H55N7O10.C2HF3O2
• Molecular Weight: 835.876
• Mol file: 99764-63-3.mol

Synonyms:LSF(NO2)-NLE-AL-METHYL ESTER;H-LEU-SER-PHE(4-NO2)-NLE-ALA-LEU-OME TFA;H-LEU-SER-P-NITRO-PHE-NLE-ALA-LEU-OME TFA;LEU-SER-PHE(NO2)-NLE-ALA-LEU-OME;LEU-SER-P-NITRO-PHE-NLE-ALA-LEU-METHYL ESTER TFA;LEUCINE-SERINE-P-NITRO-PHENYLALANINE-NLE-ALANINE-LEUCINE METHYL ESTER;Leu-Ser-p-nitro-Phe-Nle-Ala-Leu methyl ester;H-Leu-Ser-p-nitro-Phe-Nle-Ala-Leu-OMe

Chemical Property of H-LEU-SER-P-NITRO-PHE-NLE-ALA-LEU-OME TFA

Chemical Property:

• PSA: 301.17000
• LogP: 4.16750
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

H-Leu-Ser-p-nitro-Phe-Nle-Ala-Leu-OMetrifluoroacetatesalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-LEU-SER-P-NITRO-PHE-NLE-ALA-LEU-OME TFA

There total 220 articles about H-LEU-SER-P-NITRO-PHE-NLE-ALA-LEU-OME TFA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(1-oxo-2H-isoindol-2-yl)-L-phenylalanine → Leu-Ser-p-nitro-Phe-Nle-Ala-Leu-OMe*TFA (99764-63-3)

Guidance literature:

Reference yield: 89.0%

pyrrolidine (123-75-1) + 1-[N-(Tert-butoxycarbonyl)piperidin-4yl]-3-(3-chloropropyl)-1,3-dihydrobenzimidazol-2-one (442688-36-0) → Leu-Ser-p-nitro-Phe-Nle-Ala-Leu-OMe*TFA (99764-63-3)

Guidance literature:

With potassium carbonate; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;

Reference yield: 71.0%

cyclo-(D-Val-NMeArg-Gly-Asp-Mamb(5-Aca)) + succinimidyl 6-(2-benzaldehydehydrazino)nicotinate + triethylamine (121-44-8) → benzaldehyde hydrazone of cyclo-(D-Val-NMeArg-Gly-Asp-Mamb(Hydrazinonicotinyl-5-Aca)) + Leu-Ser-p-nitro-Phe-Nle-Ala-Leu-OMe*TFA (99764-63-3)

Guidance literature:

With trifluoroacetic acid; In water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

pyrrolidine

1-[N-(Tert-butoxycarbonyl)piperidin-4yl]-3-(3-chloropropyl)-1,3-dihydrobenzimidazol-2-one

N-Fmoc-Tyr-OH

1,4-di(diphenylphosphino)-butane

Downstream raw materials:

methyl-phenyl-carbamic acid 4-{2-[(pyridine-3-carbonyl)-amino]-ethyl}-phenyl ester

methyl-phenyl-carbamic acid 4-{2-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-ethyl}-phenyl ester

methyl-phenyl-carbamic acid 4-{2-[(1-methyl-piperidine-4-carbonyl)-amino]-ethyl}-phenyl ester

methyl-phenyl-carbamic acid 4-{2-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-ethyl}-phenyl ester