(S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid

Base Information

• Chemical Name: (S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid
• CAS No.: 214350-91-1
• Molecular Formula: C₂₇H₄₂N₄O₈
• Molecular Weight: 550.652
• Mol file: 214350-91-1.mol

Synonyms:(S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid

Chemical Property of (S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid

There total 1 articles about (S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

((S)-2-Oxo-oxetan-3-yl)-carbamic acid benzyl ester (26054-60-4) + 1,4-di-tert-butyl 1,4,7-triazonane-1,4-dicarboxylate (174138-01-3) → (S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid (214350-91-1)

Guidance literature:

In acetonitrile; for 48h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01532-9

Reference yield: 84.0%

methylamine hydrochloride (593-51-1) + (S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid (214350-91-1) → (S)-di-tert-butyl 7-(2-(benzyloxycarbonylamino)-3-(methylamino)-3-oxopropyl)-1,4,7-triazonane-1,4-dicarboxylate

Guidance literature:

(S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid; With benzotriazol-1-ol; 1,2-dichloro-ethane; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;

methylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201600853

Reference yield: 75.0%

7-((S)-2-Amino-2-methoxycarbonyl-ethyl)-[1,4,7]triazonane-1,4-dicarboxylic acid di-tert-butyl ester (339183-85-6) + (S)-2-(benzyloxycarbonylamino)-3-(4,7-bis(tert-butoxycarbonyl)-1,4,7-triazonan-1-yl)propanoic acid (214350-91-1) → C47H78N8O13

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01532-9

upstream raw materials:

((S)-2-Oxo-oxetan-3-yl)-carbamic acid benzyl ester

1,4-di-tert-butyl 1,4,7-triazonane-1,4-dicarboxylate

Downstream raw materials:

Z-Aib-L-ATANP(Boc)2-(Aib)2-OMe

Z-L-Iva-L-ATANP(Boc)2-(L-Iva)2-OMe