(2-(1-bromomethyl)phenyl)[2-chloro-4-(E-((1-morpholinyl)carbonyl)ethenyl)phenyl]sulfide

Base Information

Chemical Name:(2-(1-bromomethyl)phenyl)[2-chloro-4-(E-((1-morpholinyl)carbonyl)ethenyl)phenyl]sulfide
CAS No.:280752-57-0
Molecular Formula:C₂₀H₁₉BrClNO₂S
Molecular Weight:452.799
Hs Code.:

Synonyms:(2-(1-bromomethyl)phenyl)[2-chloro-4-(E-((1-morpholinyl)carbonyl)ethenyl)phenyl]sulfide

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Chemical Property of (2-(1-bromomethyl)phenyl)[2-chloro-4-(E-((1-morpholinyl)carbonyl)ethenyl)phenyl]sulfide

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Technology Process of (2-(1-bromomethyl)phenyl)[2-chloro-4-(E-((1-morpholinyl)carbonyl)ethenyl)phenyl]sulfide

There total 6 articles about (2-(1-bromomethyl)phenyl)[2-chloro-4-(E-((1-morpholinyl)carbonyl)ethenyl)phenyl]sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 280748-78-9
2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide

: 280752-57-0
(2-(1-bromomethyl)phenyl)[2-chloro-4-(E-((1-morpholinyl)carbonyl)ethenyl)phenyl]sulfide

Guidance literature:: With phosphorus tribromide; lithium bromide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm0002782

Reference yield:

: 34328-61-5
3-Chloro-4-fluorobenzaldehyde

: 280752-57-0
(2-(1-bromomethyl)phenyl)[2-chloro-4-(E-((1-morpholinyl)carbonyl)ethenyl)phenyl]sulfide

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 5 h / 70 °C

2: piperidine; pyridine / 2 h / 110 °C

3: (COCl)2; DMF / CH₂Cl₂ / 1.5 h / 20 °C

4: i-Pr₂NEt; DMAP / CH₂Cl₂ / 0.5 h

5: PBr₃; LiBr / dimethylformamide / 1 h / 20 °C

With piperidine; pyridine; dmap; oxalyl dichloride; phosphorus tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium bromide; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Condensation / 3: Chlorination / 4: Acylation / 5: Bromination;
DOI:10.1021/jm0002782

Reference yield:

: 4521-31-7
o-hydroxymethyl thiophenol

: 280752-57-0
(2-(1-bromomethyl)phenyl)[2-chloro-4-(E-((1-morpholinyl)carbonyl)ethenyl)phenyl]sulfide

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 5 h / 70 °C

2: piperidine; pyridine / 2 h / 110 °C

3: (COCl)2; DMF / CH₂Cl₂ / 1.5 h / 20 °C

4: i-Pr₂NEt; DMAP / CH₂Cl₂ / 0.5 h

5: PBr₃; LiBr / dimethylformamide / 1 h / 20 °C

With piperidine; pyridine; dmap; oxalyl dichloride; phosphorus tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium bromide; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Condensation / 3: Chlorination / 4: Acylation / 5: Bromination;
DOI:10.1021/jm0002782