2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide

Base Information

Chemical Name:2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide
CAS No.:280748-78-9
Molecular Formula:C₂₀H₂₀ClNO₃S
Molecular Weight:389.903
Hs Code.:

Synonyms:2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide

Suppliers and Price of 2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide

There total 6 articles about 2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34328-61-5
3-Chloro-4-fluorobenzaldehyde

: 280748-78-9
2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 5 h / 70 °C

2: piperidine; pyridine / 2 h / 110 °C

3: (COCl)2; DMF / CH₂Cl₂ / 1.5 h / 20 °C

4: i-Pr₂NEt; DMAP / CH₂Cl₂ / 0.5 h

With piperidine; pyridine; dmap; oxalyl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Condensation / 3: Chlorination / 4: Acylation;
DOI:10.1021/jm0002782

Reference yield:

: 4521-31-7
o-hydroxymethyl thiophenol

: 280748-78-9
2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 5 h / 70 °C

2: piperidine; pyridine / 2 h / 110 °C

3: (COCl)2; DMF / CH₂Cl₂ / 1.5 h / 20 °C

4: i-Pr₂NEt; DMAP / CH₂Cl₂ / 0.5 h

With piperidine; pyridine; dmap; oxalyl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Condensation / 3: Chlorination / 4: Acylation;
DOI:10.1021/jm0002782

Reference yield:

: 1027579-93-6
3-chloro-4-(2-hydroxymethyl-phenylsulfanyl)-benzaldehyde

: 280748-78-9
2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine; pyridine / 2 h / 110 °C

2: (COCl)2; DMF / CH₂Cl₂ / 1.5 h / 20 °C

3: i-Pr₂NEt; DMAP / CH₂Cl₂ / 0.5 h

With piperidine; pyridine; dmap; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; 1: Condensation / 2: Chlorination / 3: Acylation;
DOI:10.1021/jm0002782