Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester

Base Information

• Chemical Name: Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester
• CAS No.: 800407-47-0
• Molecular Formula: C₃₀H₅₃O₈PS
• Molecular Weight: 604.786

Synonyms:Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester

Chemical Property of Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester

There total 8 articles about Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + (3R,4R,5E)-1-(dimethoxyphosphinyl)-3-hydroxy-4-(4'-methoxybenzyloxy)-5-nonadecene (800407-46-9) → Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester (800407-47-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at -20 - 20 ℃;

DOI:10.1021/jo0487404

Reference yield:

myristylaldehyde (124-25-4,511542-15-7) → Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester (800407-47-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: Cs₂CO₃ / propan-2-ol / 2 h / 0 °C

1.2: 90 percent / propan-2-ol / 20 °C

2.1: 81 percent / L-Selectride / tetrahydrofuran / 4 h / -78 °C

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: 85 percent / dimethylformamide / 0 - 20 °C

4.1: 90 percent / HCl / acetonitrile / 4 h / 20 °C

5.1: Bu₂SnO / CHCl₃; methanol / 2 h / Heating

5.2: 98 percent / CH₂Cl₂ / 20 °C

6.1: 96 percent / K₂CO₃ / methanol / 2.5 h / 0 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

7.2: 74 percent / BF₃*Et₂O / tetrahydrofuran; hexane / -78 - -20 °C

8.1: Et₃N; DMAP / CH₂Cl₂ / -20 - 20 °C

With hydrogenchloride; dmap; n-butyllithium; L-Selectride; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

DOI:10.1021/jo0487404

Reference yield:

(2R,3R,4E)-1,2-O-isopropylidene-3-hydroxy-4-octadecene-1,2-diol (121998-82-1) → Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester (800407-47-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 85 percent / dimethylformamide / 0 - 20 °C

2.1: 90 percent / HCl / acetonitrile / 4 h / 20 °C

3.1: Bu₂SnO / CHCl₃; methanol / 2 h / Heating

3.2: 98 percent / CH₂Cl₂ / 20 °C

4.1: 96 percent / K₂CO₃ / methanol / 2.5 h / 0 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: 74 percent / BF₃*Et₂O / tetrahydrofuran; hexane / -78 - -20 °C

6.1: Et₃N; DMAP / CH₂Cl₂ / -20 - 20 °C

With hydrogenchloride; dmap; n-butyllithium; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo0487404

upstream raw materials:

methanesulfonyl chloride

(3R,4R,5E)-1-(dimethoxyphosphinyl)-3-hydroxy-4-(4'-methoxybenzyloxy)-5-nonadecene

myristylaldehyde

(2R,3R,4E)-1,2-O-isopropylidene-3-hydroxy-4-octadecene-1,2-diol

Downstream raw materials:

(3S,4R,5E)-3-tert-butoxycarbonylamino-1-(dimethoxyphosphinyl)-4-(4'-methoxybenzyloxy)-5-nonadecene

(3S,4R,5E)-3-azido-1-(dimethoxyphosphinyl)-4-(4'-methoxybenzyloxy)-5-nonadecene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 800407-47-0 Methanesulfonic acid (E)-(1R,2R)-1-[2-(dimethoxy-phosphoryl)-ethyl]-2-(4-methoxy-benzyloxy)-heptadec-3-enyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send