1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine

Base Information

Chemical Name:1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine
CAS No.:128496-07-1
Molecular Formula:C₂₃H₁₉F₂N₃O₆S
Molecular Weight:503.483
Hs Code.:

1-<5-O-benzoyl-2-deoxy-fluoro-3-O-<phenoxy(thiocarbonyl)>-β-D-arabinofuranosyl>)-5-fluorocytosine

Synonyms:1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine

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Technology Process of 1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine

There total 3 articles about 1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 128496-06-0
1-(5-O-benzoyl-2-deoxy-fluoro-β-D-arabinofuranosyl)-5-fluorocytosine

: 1005-56-7
phenylcarbonochloridothioate

: 128496-07-1
1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine

Guidance literature:: With dmap; In acetonitrile; at 5 ℃; for 2h;
DOI:10.1021/jm00170a015

Reference yield:

: 97614-44-3
2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide

: 128496-07-1
1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) hexamethyldisilazane, amonium sulfate / 1.) reflux, 2.5 h, 2.) chloroform, reflux, 48 h

2: 66 percent / NH₃ / methanol / 1.5 h / Ambient temperature

3: 78 percent / 4-(dimethylamino)pyridine / acetonitrile / 2 h / 5 °C

With dmap; ammonium sulfate; ammonia; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; acetonitrile;
DOI:10.1021/jm00170a015

Reference yield:

: 128496-05-9
1-(3,5-O-dibenzoyl-2-fluoro-β-D-arabinofuranosyl)-5-fluorocytosine

: 128496-07-1
1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / NH₃ / methanol / 1.5 h / Ambient temperature

2: 78 percent / 4-(dimethylamino)pyridine / acetonitrile / 2 h / 5 °C

With dmap; ammonia; In methanol; acetonitrile;
DOI:10.1021/jm00170a015