11-(N-ethoxycarbonyl-N-methylaminomethyl)-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

Base Information

Chemical Name:11-(N-ethoxycarbonyl-N-methylaminomethyl)-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine
CAS No.:120098-79-5
Molecular Formula:C₂₃H₂₄N₂O₃
Molecular Weight:376.455
Hs Code.:

Synonyms:11-(N-ethoxycarbonyl-N-methylaminomethyl)-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

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Chemical Property of 11-(N-ethoxycarbonyl-N-methylaminomethyl)-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

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Technology Process of 11-(N-ethoxycarbonyl-N-methylaminomethyl)-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

There total 6 articles about 11-(N-ethoxycarbonyl-N-methylaminomethyl)-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 541-41-3
chloroformic acid ethyl ester

: 120098-58-0
11-(dimethylamino)methyl-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

: 120098-79-5
11-(N-ethoxycarbonyl-N-methylaminomethyl)-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

Guidance literature:: With potassium carbonate; In benzene; at 65 ℃; for 6h;
DOI:10.1002/jhet.5570300132

Reference yield:

: 55095-24-4
α-(2-fluorophenyl)benzenemethanamine

: 120098-79-5
11-(N-ethoxycarbonyl-N-methylaminomethyl)-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / acetic acid / 1.5 h / Heating

2: 1.) zinc chloride, hydrogen chloride, 2.) H₂O / 1.) Et₂O, 6 h, 2.) 95 deg C, 2 h

3: 89 percent / methanol / 2 h / 85 °C

4: 83 percent / NaBH₄ / propan-2-ol / 6 h / Heating

5: sodium hydride / benzene; dimethylformamide / 3 h / 80 °C

6: potassium carbonate / benzene / 6 h / 65 °C

With hydrogenchloride; sodium tetrahydroborate; water; sodium hydride; potassium carbonate; zinc(II) chloride; In methanol; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; benzene;
DOI:10.1002/jhet.5570300132

Reference yield:

: 120098-72-8
1-<(2-fluorophenyl)phenylmethyl>pyrrole

: 120098-79-5
11-(N-ethoxycarbonyl-N-methylaminomethyl)-5-phenyl-5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) zinc chloride, hydrogen chloride, 2.) H₂O / 1.) Et₂O, 6 h, 2.) 95 deg C, 2 h

2: 89 percent / methanol / 2 h / 85 °C

3: 83 percent / NaBH₄ / propan-2-ol / 6 h / Heating

4: sodium hydride / benzene; dimethylformamide / 3 h / 80 °C

5: potassium carbonate / benzene / 6 h / 65 °C

With hydrogenchloride; sodium tetrahydroborate; water; sodium hydride; potassium carbonate; zinc(II) chloride; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; benzene;
DOI:10.1002/jhet.5570300132