N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide
CAS No.:1254300-83-8
Molecular Formula:C₂₄H₂₆FN₅O₅
Molecular Weight:483.499
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

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Chemical Property of N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

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Technology Process of N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

There total 8 articles about N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1355028-60-2
methyl 3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

: 140-75-0
para-fluorobenzylamine

: 1254300-83-8
N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

Guidance literature:: In methanol; at 70 ℃; for 15h;

Reference yield:

: 13535-01-8
3-amino-5-bromopyridine

: 1254300-83-8
N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: chloroformic acid ethyl ester; pyridine

1.2: 20 h / 30 °C

2.1: 10 h / 140 °C

3.1: copper(l) iodide; sodium nitrite; sulfuric acid / water / 4 h / 0 - 80 °C

4.1: 24 h / 60 °C

5.1: tin(II) chloride dihdyrate / ethanol / 15 h / 80 °C / Inert atmosphere

6.1: acetic acid; 4, 5-diaminofluorescein / methanol / 24 h / 70 °C

7.1: methanol / 15 h / 70 °C

With pyridine; copper(l) iodide; tin(II) chloride dihdyrate; sulfuric acid; chloroformic acid ethyl ester; acetic acid; 4, 5-diaminofluorescein; sodium nitrite; In methanol; ethanol; water;

Reference yield:

: 433226-05-2
5-bromo-2-nitropyridine-3-ylamine

: 1254300-83-8
N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 10 h / 140 °C

2: copper(l) iodide; sodium nitrite; sulfuric acid / water / 4 h / 0 - 80 °C

3: 24 h / 60 °C

4: tin(II) chloride dihdyrate / ethanol / 15 h / 80 °C / Inert atmosphere

5: acetic acid; 4, 5-diaminofluorescein / methanol / 24 h / 70 °C

6: methanol / 15 h / 70 °C

With copper(l) iodide; tin(II) chloride dihdyrate; sulfuric acid; acetic acid; 4, 5-diaminofluorescein; sodium nitrite; In methanol; ethanol; water;