3-AMINO-5-BROMO-2-NITROPYRIDINE

Base Information

• Chemical Name: 3-AMINO-5-BROMO-2-NITROPYRIDINE
• CAS No.: 433226-05-2
• Molecular Formula: C5H4 Br N3 O2
• Molecular Weight: 218.01
• Hs Code.: 2933399090
• Mol file: 433226-05-2.mol

Synonyms:(5-Bromo-2-nitropyridin-3-yl)amine

Chemical Property of 3-AMINO-5-BROMO-2-NITROPYRIDINE

Chemical Property:

• Boiling Point: 404.0±40.0 °C(Predicted)
• PKA: -3.55±0.25(Predicted)
• PSA: 84.73000
• Density: 1.929±0.06 g/cm3(Predicted)
• LogP: 2.43890
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

5-bromo-2-nitropyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-AMINO-5-BROMO-2-NITROPYRIDINE

There total 6 articles about 3-AMINO-5-BROMO-2-NITROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-bromo-5-(ethoxycarbonyl)amino-2-nitropyridine (152684-25-8) → 5-bromo-2-nitropyridine-3-ylamine (433226-05-2)

Guidance literature:

With water; potassium hydroxide; In tetrahydrofuran; at 90 ℃;

Reference yield: 94.1%

2-nitro-3-propoxycarbonylamino-5-bromopyridine → 5-bromo-2-nitropyridine-3-ylamine (433226-05-2)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 - 90 ℃; for 2h;

DOI:10.1016/j.ejmech.2017.07.012

Reference yield:

3-amino-5-bromopyridine (13535-01-8) → 5-bromo-2-nitropyridine-3-ylamine (433226-05-2)

Guidance literature:

3-amino-5-bromopyridine; With pyridine; chloroformic acid ethyl ester;

With sulfuric acid; nitric acid; at 30 ℃; for 20h;

With potassium hydroxide; In ethanol; water;

upstream raw materials:

3-bromo-5-(ethoxycarbonyl)amino-2-nitropyridine

3-bromo-5-(ethoxycarbonyl)aminopyridine

3-amino-5-bromopyridine

5-bromo-3-pyridinecarboxylic acid

Downstream raw materials:

2-nitro-5-(4-(tert-butoxycarbonylamino)phenoxy)pyridine-3-ylamine

N-(4-fluorobenzyl)-3-hydroxy-7,9-dimorpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

C₁₁H₉N₃O₂

C₃₀H₃₀N₆O₅

Refernces

• 1、 -. "A two-aryl pyridine derivative and its preparation method and application". . . Retrieved 2018/04/02.
• 2、 -. "Aminoheteroaryl benzamides as kinase inhibitors". Page/Page column 82; 83. . Retrieved 2016/02/15.