6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine

Base Information

Chemical Name:6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine
CAS No.:142613-47-6
Molecular Formula:C₄₀H₄₅N₅O₃Si
Molecular Weight:671.914
Hs Code.:

6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N<sup>2</sup>-(monomethoxytrityl)guanine

Synonyms:6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine

Suppliers and Price of 6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine

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Technology Process of 6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine

There total 4 articles about 6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 142613-55-6
6-O-benzyl-9-(2-hydroxyethyl)-N²-(monomethoxytrityl)guanine

: 142613-47-6
6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00094a005

Reference yield:

: 142613-45-4
9-(2-acetoxyethyl)-6-O-benzylguanine

: 142613-47-6
6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Et₃N, 4-(dimethylamino)pyridine / dimethylformamide / 16 h / 45 °C

2: potassium carbonate / methanol / 1 h / Ambient temperature

3: 98 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; potassium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00094a005

Reference yield:

: 142613-46-5
9-(2-acetoxyethyl)-6-O-benzyl-N²-(monomethoxytrityl)guanine

: 142613-47-6
6-O-benzyl-9-<2-(tert-butyldimethylsiloxy)ethyl>-N²-(monomethoxytrityl)guanine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 1 h / Ambient temperature

2: 98 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; potassium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00094a005