11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1-pyrrolidin-1-yl-undecan-1-one

Base Information

• Chemical Name: 11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1-pyrrolidin-1-yl-undecan-1-one
• CAS No.: 220469-53-4
• Molecular Formula: C₃₁H₄₁NO₃S
• Molecular Weight: 507.737

Synonyms:11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1-pyrrolidin-1-yl-undecan-1-one

Chemical Property of 11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1-pyrrolidin-1-yl-undecan-1-one

Chemical Property:

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Technology Process of 11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1-pyrrolidin-1-yl-undecan-1-one

There total 6 articles about 11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1-pyrrolidin-1-yl-undecan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

pyrrolidine (123-75-1) + 11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-undecanoyl chloride → 11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1-pyrrolidin-1-yl-undecan-1-one (220469-53-4)

Guidance literature:

In dichloromethane;

DOI:10.1002/(SICI)1521-4184(19989)331:9<283::AID-ARDP283>3.0.CO;2-N

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → 11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1-pyrrolidin-1-yl-undecan-1-one (220469-53-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 52 percent / AlCl₃ / 1,2-dichloro-ethane / 1 h / Ambient temperature

2: 94 percent / AlCl₃, LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

3: 1) Mg, I₂ / 1) Et₂O, THF, reflux, 1 h, 2) Et₂O, THF, 35 deg C, 10 h

4: PCl₅ / 0.5 h / 60 °C

5: 67 percent / CH₂Cl₂

With lithium aluminium tetrahydride; aluminium trichloride; phosphorus pentachloride; iodine; magnesium; In diethyl ether; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/(SICI)1521-4184(19989)331:9<283::AID-ARDP283>3.0.CO;2-N

Reference yield:

10-bromodecanoyl chloride (73674-11-0) → 11-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1-pyrrolidin-1-yl-undecan-1-one (220469-53-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 52 percent / AlCl₃ / 1,2-dichloro-ethane / 1 h / Ambient temperature

2: 94 percent / AlCl₃, LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

3: 1) Mg, I₂ / 1) Et₂O, THF, reflux, 1 h, 2) Et₂O, THF, 35 deg C, 10 h

4: PCl₅ / 0.5 h / 60 °C

5: 67 percent / CH₂Cl₂

With lithium aluminium tetrahydride; aluminium trichloride; phosphorus pentachloride; iodine; magnesium; In diethyl ether; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/(SICI)1521-4184(19989)331:9<283::AID-ARDP283>3.0.CO;2-N

upstream raw materials:

pyrrolidine

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

10-bromodecanoyl chloride

3-(10-bromodecyl)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

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