{1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester

Base Information

Chemical Name:{1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester
CAS No.:886450-34-6
Molecular Formula:C₃₂H₄₇NO₉
Molecular Weight:589.726
Hs Code.:

{1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid <i>tert</i>-butyl ester

Synonyms:{1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester

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Chemical Property of {1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester

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Technology Process of {1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester

There total 6 articles about {1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 886450-33-5
{1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-carbamic acid tert-butyl ester

: 74-88-4
methyl iodide

: 886450-34-6
{1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; for 12h; Heating;
DOI:10.1002/anie.200503982

Reference yield:

: 886450-30-2
{2-[2-azido-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-3,5,6-trimethoxy-4-methyl-benzyloxy}-tert-butyl-dimethyl-silane

: 886450-34-6
{1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / Pd/C / ethyl acetate / 5 h / 25 °C

2: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 25 °C

3: 98 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran; dimethylformamide / 5 h / 0 - 25 °C

4: 93 percent / NaH / tetrahydrofuran; dimethylformamide / 12 h / Heating

With tetrabutyl ammonium fluoride; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/anie.200503982

Reference yield:

: 271578-70-2
4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4,6-trimethoxy-5-methyl-phenyl]-but-2-en-1-ol

: 886450-34-6
{1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: molecular sieves 4 Angstroem; Ti(OiPr)4; tBuOOH / D-diethyl tartrate / 24 h / -20 °C

1.2: Ti(OiPr)2(N₃)2 / benzene / 5 h / 80 °C

2.1: 100 percent / TsOH*H₂O / acetone / 0.17 h / 25 °C

3.1: 100 percent / H₂ / Pd/C / ethyl acetate / 5 h / 25 °C

4.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 25 °C

5.1: 98 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran; dimethylformamide / 5 h / 0 - 25 °C

6.1: 93 percent / NaH / tetrahydrofuran; dimethylformamide / 12 h / Heating

With titanium(IV) isopropylate; tert.-butylhydroperoxide; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; palladium on activated charcoal; Diethyl tartrate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetone; 1.1: Sharpless epoxidation;
DOI:10.1002/anie.200503982