5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Base Information

Chemical Name:5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide
CAS No.:884602-75-9
Molecular Formula:C₂₅H₂₁F₄N₅O
Molecular Weight:483.468
Hs Code.:

Synonyms:5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide

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Chemical Property of 5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide

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Technology Process of 5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide

There total 8 articles about 5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 857265-74-8
5-ethynylpyrimidine-2-amine

: 926036-43-3
2-fluoro-5-iodo-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide

: 884602-75-9
5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In acetonitrile; at 80 ℃;
DOI:10.1021/jm061112p

Reference yield:

: 110-89-4
piperidine

: 884602-75-9
5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium bicarbonate / tetrahydrofuran / 14 h / 70 °C

2: H₂ / Pd/C / methanol / 20 °C

3: iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

4: 100 percent / Et₃N / PdCl₂(PPh₃)2; CuI / acetonitrile / 80 °C

With hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 4: Sonogashira coupling;
DOI:10.1021/jm061112p

Reference yield:

: 186584-73-6
2-fluoro-5-iodobenzoyl chloride

: 884602-75-9
5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

2: 100 percent / Et₃N / PdCl₂(PPh₃)2; CuI / acetonitrile / 80 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; acetonitrile; 2: Sonogashira coupling;
DOI:10.1021/jm061112p