Phosphoric acid (2R,3S,4R)-4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,4R)-4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester
• CAS No.: 265137-13-1
• Molecular Formula: C₄₄H₃₉ClN₅O₉P
• Molecular Weight: 848.249
• Mol file: 265137-13-1.mol

Synonyms:Phosphoric acid (2R,3S,4R)-4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Chemical Property of Phosphoric acid (2R,3S,4R)-4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,4R)-4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

There total 1 articles about Phosphoric acid (2R,3S,4R)-4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

N-(9-{(3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl}-9H-purin-6-yl)-benzamide (215032-02-3) → Phosphoric acid (2R,3S,4R)-4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (265137-13-1)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0960-894X(99)00677-0

Reference yield: 66.0%

(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl acetate (17182-39-7) + Phosphoric acid (2R,3S,4R)-4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (265137-13-1) → N-benzoyl-5'-dimethoxytrityl-1-deoxy-2-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyldeoxycytidine-5'-yl)]phosphate (265137-14-2)

Guidance literature:

With pyridine; TPS-TAZ; at 25 ℃;

DOI:10.1016/S0960-894X(99)00677-0

Reference yield:

Phosphoric acid (2R,3S,4R)-4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (265137-13-1) → N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate (265137-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / TPS-TAZ; pyridine / 25 °C

2: 56 percent / 2 percent CHCl₂COOH / CH₂Cl₂ / 0 °C

With pyridine; dichloro-acetic acid; TPS-TAZ; In dichloromethane; 1: Esterification / 2: Hydrolysis;

DOI:10.1016/S0960-894X(99)00677-0

upstream raw materials:

N-(9-{(3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl}-9H-purin-6-yl)-benzamide

Downstream raw materials:

N-benzoyl-5'-dimethoxytrityl-1-deoxy-2-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyldeoxycytidine-5'-yl)]phosphate

N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate