N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate

Base Information

• Chemical Name: N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate
• CAS No.: 265137-15-3
• Molecular Formula: C₄₁H₃₈ClN₈O₁₂P
• Molecular Weight: 901.226
• Mol file: 265137-15-3.mol

Synonyms:N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate

Chemical Property of N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate

There total 7 articles about N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-benzoyl-5'-dimethoxytrityl-1-deoxy-2-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyldeoxycytidine-5'-yl)]phosphate (265137-14-2) → N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate (265137-15-3)

Guidance literature:

With dichloro-acetic acid; In dichloromethane; at 0 ℃;

DOI:10.1016/S0960-894X(99)00677-0

Reference yield:

(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl acetate (17182-39-7) → N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate (265137-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / 2,4,6-triisopropylbenzenesulfonyltetrazolide; pyridine / 1 h / 20 °C

2: 56 percent / dichloroacetic acid / CH₂Cl₂ / 0.05 h / 0 °C

With pyridine; dichloro-acetic acid; 2,4,6-triisopropylbenzenesulfonyl tetrazolide; In dichloromethane; 1: Phosphorylation / 2: Detritylation;

DOI:10.1021/ja992528d

Reference yield:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyl-deoxycytidine-5'-yl)]phosphate (265137-15-3)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / 0 °C

2: 66 percent / 2,4,6-triisopropylbenzenesulfonyltetrazolide; pyridine / 1 h / 20 °C

3: 56 percent / dichloroacetic acid / CH₂Cl₂ / 0.05 h / 0 °C

With pyridine; dichloro-acetic acid; 2,4,6-triisopropylbenzenesulfonyl tetrazolide; In tetrahydrofuran; dichloromethane; 1: Phosphorylation / 2: Phosphorylation / 3: Detritylation;

DOI:10.1021/ja992528d

upstream raw materials:

N-benzoyl-5'-dimethoxytrityl-1-deoxy-2-isoadenosine-3'-[(2-chlorophenyl)(N-benzoyl-3'-O-acetyldeoxycytidine-5'-yl)]phosphate

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl acetate

2-chlorophenyl dichlorophosphate