6-isopropoxy-4-methoxy-2-(4-methoxybenzyl)-5-methyl-2,3-dihydro-1H-isoindol-1-one

Base Information

Chemical Name:6-isopropoxy-4-methoxy-2-(4-methoxybenzyl)-5-methyl-2,3-dihydro-1H-isoindol-1-one
CAS No.:863647-52-3
Molecular Formula:C₂₁H₂₅NO₄
Molecular Weight:355.434
Hs Code.:

Synonyms:6-isopropoxy-4-methoxy-2-(4-methoxybenzyl)-5-methyl-2,3-dihydro-1H-isoindol-1-one

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Chemical Property of 6-isopropoxy-4-methoxy-2-(4-methoxybenzyl)-5-methyl-2,3-dihydro-1H-isoindol-1-one

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Technology Process of 6-isopropoxy-4-methoxy-2-(4-methoxybenzyl)-5-methyl-2,3-dihydro-1H-isoindol-1-one

There total 10 articles about 6-isopropoxy-4-methoxy-2-(4-methoxybenzyl)-5-methyl-2,3-dihydro-1H-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 863647-46-5
N-(6-bromo-4-isopropoxy-2-methoxy-3-methyl)-N-(4-methoxybenzyl)carbamic acid methyl ester

: 863647-52-3
6-isopropoxy-4-methoxy-2-(4-methoxybenzyl)-5-methyl-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; pentane; at -100 ℃; for 0.5h;
DOI:10.1039/b504602e

Reference yield:

: 863647-48-7
4-isopropoxy-2-methoxy-3-methylbenzaldehyde

: 863647-52-3
6-isopropoxy-4-methoxy-2-(4-methoxybenzyl)-5-methyl-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 66 percent / toluene / 3 h / Heating

2.1: tBuLi / pentane; diethyl ether / 6 h / 20 °C

2.2: 1,2-dibromotetrachloroethane / pentane; diethyl ether / 12 h / 20 °C

3.1: 1.49 percent / aq. HCl / 0.5 h

4.1: toluene / 3 h / Heating

5.1: 1.39 g / NaBH₄ / methanol / 2 h / 20 °C

6.1: 96 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

7.1: 55 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 °C

With hydrogenchloride; sodium tetrahydroborate; tert.-butyl lithium; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; pentane;
DOI:10.1039/b504602e

Reference yield:

: 863647-47-6
2-hydroxy-4-isopropoxy-3-methylbenzaldehyde

: 863647-52-3
6-isopropoxy-4-methoxy-2-(4-methoxybenzyl)-5-methyl-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 57 percent / K₂CO₃ / dimethylformamide / 12 h / 40 °C

2.1: 66 percent / toluene / 3 h / Heating

3.1: tBuLi / pentane; diethyl ether / 6 h / 20 °C

3.2: 1,2-dibromotetrachloroethane / pentane; diethyl ether / 12 h / 20 °C

4.1: 1.49 percent / aq. HCl / 0.5 h

5.1: toluene / 3 h / Heating

6.1: 1.39 g / NaBH₄ / methanol / 2 h / 20 °C

7.1: 96 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

8.1: 55 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 °C

With hydrogenchloride; sodium tetrahydroborate; tert.-butyl lithium; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; pentane;
DOI:10.1039/b504602e