1-(6-(4-fluorobenzyloxy)quinazolin-7-yl)-3-(4-(trifluoromethyl)phenyl)urea

Base Information

Chemical Name:1-(6-(4-fluorobenzyloxy)quinazolin-7-yl)-3-(4-(trifluoromethyl)phenyl)urea
CAS No.:1621090-29-6
Molecular Formula:C₂₃H₁₆F₄N₄O₂
Molecular Weight:456.399
Hs Code.:

Synonyms:1-(6-(4-fluorobenzyloxy)quinazolin-7-yl)-3-(4-(trifluoromethyl)phenyl)urea

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Chemical Property of 1-(6-(4-fluorobenzyloxy)quinazolin-7-yl)-3-(4-(trifluoromethyl)phenyl)urea

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Technology Process of 1-(6-(4-fluorobenzyloxy)quinazolin-7-yl)-3-(4-(trifluoromethyl)phenyl)urea

There total 7 articles about 1-(6-(4-fluorobenzyloxy)quinazolin-7-yl)-3-(4-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1621090-72-9
6-(4-fluorobenzyloxy)quinazolin-7-amine

: 1548-13-6
p-trifluoromethyl-phenylisocyanate

: 1621090-29-6
1-(6-(4-fluorobenzyloxy)quinazolin-7-yl)-3-(4-(trifluoromethyl)phenyl)urea

Guidance literature:: In tetrahydrofuran; at 85 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.ejmech.2014.07.027

Reference yield: 81.0%

: 1621090-29-6
1-(6-(4-fluorobenzyloxy)quinazolin-7-yl)-3-(4-(trifluoromethyl)phenyl)urea

Guidance literature:: In tetrahydrofuran; at 85 ℃; for 18h;

Reference yield:

: 51-28-5
2,4-Dinitrophenol

: 1621090-29-6
1-(6-(4-fluorobenzyloxy)quinazolin-7-yl)-3-(4-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique

1.2: 8 h / 75 °C / Inert atmosphere; Schlenk technique

2.1: 10% Pt/activated carbon; hydrogen / methanol / 6 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Schlenk technique

4.1: hexamethylenetetramine; trifluoroacetic acid / 1 h / Inert atmosphere; Schlenk technique; Reflux

4.2: 4 h / Inert atmosphere; Schlenk technique; Reflux

5.1: tetrahydrofuran / 85 °C / Inert atmosphere; Schlenk technique

With hexamethylenetetramine; 10% Pt/activated carbon; hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/j.ejmech.2014.07.027