tert-butyl (2R,3S)-3-[(tert-butyldimethylsilyloxy)methyl]-2-phenylpyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (2R,3S)-3-[(tert-butyldimethylsilyloxy)methyl]-2-phenylpyrrolidine-1-carboxylate
• CAS No.: 1238895-36-7
• Molecular Formula: C₂₂H₃₇NO₃Si
• Molecular Weight: 391.626

Synonyms:tert-butyl (2R,3S)-3-[(tert-butyldimethylsilyloxy)methyl]-2-phenylpyrrolidine-1-carboxylate

Chemical Property of tert-butyl (2R,3S)-3-[(tert-butyldimethylsilyloxy)methyl]-2-phenylpyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl (2R,3S)-3-[(tert-butyldimethylsilyloxy)methyl]-2-phenylpyrrolidine-1-carboxylate

There total 1 articles about tert-butyl (2R,3S)-3-[(tert-butyldimethylsilyloxy)methyl]-2-phenylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

tert-butyl [(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-enyl]carbamate (1238895-31-2) → tert-butyl (2R,3S)-3-[(tert-butyldimethylsilyloxy)methyl]-2-phenylpyrrolidine-1-carboxylate (1238895-36-7)

Guidance literature:

tert-butyl [(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-enyl]carbamate; With Schwartz's reagent; In dichloromethane; Inert atmosphere;

With iodine; In dichloromethane; for 2h; Inert atmosphere;

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201000255

Reference yield: 100.0%

tert-butyl (2R,3S)-3-[(tert-butyldimethylsilyloxy)methyl]-2-phenylpyrrolidine-1-carboxylate (1238895-36-7) → (2R,3S)-3-Hydroxymethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201000255

upstream raw materials:

tert-butyl [(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-enyl]carbamate

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