triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> S-(2,4-dichlorobenzyl) phosphorodithioate

Base Information

• Chemical Name: triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> S-(2,4-dichlorobenzyl) phosphorodithioate
• CAS No.: 129789-68-0
• Molecular Formula: C₆H₁₅N*C₃₈H₃₇Cl₂N₂O₈PS₂
• Molecular Weight: 916.924

Synonyms:triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> S-(2,4-dichlorobenzyl) phosphorodithioate

Chemical Property of triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> S-(2,4-dichlorobenzyl) phosphorodithioate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> S-(2,4-dichlorobenzyl) phosphorodithioate

There total 6 articles about triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> S-(2,4-dichlorobenzyl) phosphorodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5'-O-Dimethoxytritylthymidine-3'-O-[β-cyanoethyl-(S-2,4-dichlorobenzyl)]-phosphorodithioate (129789-64-6) + triethylamine (121-44-8) → triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> S-(2,4-dichlorobenzyl) phosphorodithioate (129789-68-0)

Guidance literature:

In acetonitrile; for 3h; Ambient temperature;

DOI:10.1016/S0040-4039(00)88887-5

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] (98796-51-1) → triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> S-(2,4-dichlorobenzyl) phosphorodithioate (129789-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) tetrazole, 2) sulfur, 2,6-lutidine / 1) CH₃CN, 40 min, 2) toluene, 1 h, rt

2: 93 percent / acetonitrile / 3 h / Ambient temperature

With 2,6-dimethylpyridine; 1H-tetrazole; sulfur; In acetonitrile;

DOI:10.1016/S0040-4039(00)88887-5

Reference yield:

2,4-dichlorobenzyl mercaptan (59293-67-3) → triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> S-(2,4-dichlorobenzyl) phosphorodithioate (129789-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) tetrazole, 2) sulfur, 2,6-lutidine / 1) CH₃CN, 40 min, 2) toluene, 1 h, rt

2: 93 percent / acetonitrile / 3 h / Ambient temperature

With 2,6-dimethylpyridine; 1H-tetrazole; sulfur; In acetonitrile;

DOI:10.1016/S0040-4039(00)88887-5

upstream raw materials:

5'-O-Dimethoxytritylthymidine-3'-O-[β-cyanoethyl-(S-2,4-dichlorobenzyl)]-phosphorodithioate

triethylamine

O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] S-(2,4-dichlorobenzyl) O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

2,4-Dichlorobenzyl chloride

Downstream raw materials:

C₅₈H₅₇Cl₄N₅O₁₃P₂S₄

O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] S-(2,4-dichlorobenzyl) O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

C₅₀H₅₁Cl₂N₄O₁₄PS

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