(2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate

Base Information

Chemical Name:(2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate
CAS No.:327025-11-6
Molecular Formula:C₁₉H₂₈INO₇
Molecular Weight:509.338
Hs Code.:

Synonyms:(2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate

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Technology Process of (2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate

There total 4 articles about (2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 327025-10-5
(2S)-methyl-[2-tert-butoxycarbonylamino-4-(3,4,5-trimethoxyphenyl)]butanoate

: 327025-11-6
(2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate

Guidance literature:: With iodine; silver trifluoroacetate; sodium hydrogencarbonate; In chloroform; at 0 ℃; for 2h;
DOI:10.1016/S0040-4020(00)00862-0

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 327025-11-6
(2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc-copper couple / benzene; N,N-dimethyl-acetamide / 3 h / 20 °C / sonication

1.2: 31 percent / bis(triphenylphosphine)palladium dichloride / benzene; N,N-dimethyl-acetamide / 2 h / sonication

2.1: 91 percent / H₂ / Pd/C / ethanol; H₂O / 22 h / 3102.89 Torr

3.1: 93 percent / NaHCO₃; silver trifluoroacetate; I₂ / CHCl₃ / 2 h / 0 °C

With zinc copper; hydrogen; iodine; silver trifluoroacetate; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl acetamide; water; benzene;
DOI:10.1016/S0040-4020(00)00862-0

Reference yield:

: 93267-04-0,170848-34-7,889670-02-4
N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

: 327025-11-6
(2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc-copper couple / benzene; N,N-dimethyl-acetamide / 3 h / 20 °C / sonication

1.2: 31 percent / bis(triphenylphosphine)palladium dichloride / benzene; N,N-dimethyl-acetamide / 2 h / sonication

2.1: 91 percent / H₂ / Pd/C / ethanol; H₂O / 22 h / 3102.89 Torr

3.1: 93 percent / NaHCO₃; silver trifluoroacetate; I₂ / CHCl₃ / 2 h / 0 °C

With zinc copper; hydrogen; iodine; silver trifluoroacetate; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl acetamide; water; benzene;
DOI:10.1016/S0040-4020(00)00862-0